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Oxidative stress genes involved in the virulence-dependent susceptibility to antibiotics in Pseudomonas aeruginosa

2021Conference object Open access
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dc.contributor.authorCoelho, Pedro Barata
dc.contributor.authorFernandes, Ruben
dc.contributor.authorSilva, Carina
dc.contributor.authorOliveira, Marco
dc.contributor.authorVeiga, Marlene
dc.contributor.authorSá, Sara
dc.contributor.authorVieira, André
dc.contributor.authorGuedes, Carla
dc.contributor.authorBaylina, Pilar
dc.date.accessioned2024-10-15T14:11:32Z
dc.date.available2024-10-15T14:11:32Z
dc.date.issued2021
dc.description.abstractPseudomonas aeruginosa is a Gram-negative opportunistic pathogen which rarely causes disease in healthy people. P. aeruginosa, in particular strain PAO1 is also a biological model for studying virulence and bacterial social traits, such as quorum sensing, SOS response among other. Antibiotic response is dependent, among several other factors, to the response to environmental stress conditions. The present study aims to understand the role of 10 PAO1 oxidative gene mutants in the response to antibiotic stress in elastase, protease and pyocyanin-dependent virulence factors. PAO1 was stressed to several antibiotics (penicilins, cephalosporins, macrolides, and quinolones), and the virulence proteins were measured by means of spectroscopic methods. Viability was measured by means of Erythrosin B. PAO1 GGT, GLO1, RubA2, GSH A mutants were the most susceptible to the production of virulence-dependent factors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCoelho, P. B., Fernandes, R., Silva, C., Oliveira, M., Veiga, M., Sá, S., Vieira, A., Guedes, C., & Baylina, P. (2021). Oxidative stress genes involved in the virulence-dependent susceptibility to antibiotics in Pseudomonas aeruginosa. Livro de resumos XXVIII Congreso Nacional de Microbiología, 209.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26244
dc.language.isoengpt_PT
dc.publisherSociedade Espanhola de Microbiologiapt_PT
dc.relation.publisherversionhttps://digital.csic.es/bitstream/10261/270690/1/XVIII-Congreso-Nacional-de-Microbiologi%CC%81a-FINAL-7.pdfpt_PT
dc.subjectPseudomonas aeruginosapt_PT
dc.subjectPathogenpt_PT
dc.titleOxidative stress genes involved in the virulence-dependent susceptibility to antibiotics in Pseudomonas aeruginosapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage209pt_PT
oaire.citation.titleLivro de resumos XXVIII Congreso Nacional de Microbiologíapt_PT
person.familyNameFernandes
person.familyNameGuedes
person.familyNameBAYLINA MACHADO
person.givenNameRúben
person.givenNameCarla
person.givenNamePILAR
person.identifier635792
person.identifier1888845
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.ciencia-id2B11-8C00-A60D
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-3277-7821
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridD-3704-2017
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id57447314300
person.identifier.scopus-author-id56534079700
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication917f7713-0a35-4ef0-ae56-0784f7fc2187
relation.isAuthorOfPublicationa1736eb9-65d6-4da5-873e-1b36f7b6e0fb
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscoverya1736eb9-65d6-4da5-873e-1b36f7b6e0fb

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