Publication
Mechanisms of paroxysmal nocturnal hemoglobinuria clonal expansion
| dc.contributor.author | Peixoto, Vanda | |
| dc.contributor.author | Vieira da Silva, Manuela | |
| dc.contributor.author | Prudêncio, Cristina | |
| dc.date.accessioned | 2024-06-17T14:32:33Z | |
| dc.date.available | 2024-06-17T14:32:33Z | |
| dc.date.issued | 2018-05-18 | |
| dc.description.abstract | Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare, acquired clonal disease of bone marrow stem-cells, genetically characterized by the somatic mutation of the phosphatidylinositol glycan class A (PIG-A) gene. That leads to defective synthesis of glycosylphosphatidylinositol (GPI) responsible for anchorage and fixation of surface proteins like complement decay-accelerating factor (DAF/CD55) and membrane inhibitor of reactive lysis (MIRL/CD59). These proteins protect red blood cells from lysis by activated complement, leading to intravascular hemolysis. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Peixoto, V., Vieira, M., & Prudêncio, C. (2018). Mechanisms of paroxysmal nocturnal hemoglobinuria clonal expansion. Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology, 48. https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdf | pt_PT |
| dc.identifier.isbn | 978-989-20-8533-3 | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/25679 | |
| dc.language.iso | eng | pt_PT |
| dc.publisher | Escola Superior de Saúde P.Porto | pt_PT |
| dc.relation.publisherversion | https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdf | pt_PT |
| dc.subject | Paroxysmal nocturnal hemoglobinuria | pt_PT |
| dc.subject | PIG-A gene | pt_PT |
| dc.subject | Clonal expansion | pt_PT |
| dc.title | Mechanisms of paroxysmal nocturnal hemoglobinuria clonal expansion | pt_PT |
| dc.type | conference object | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Porto | pt_PT |
| oaire.citation.startPage | 48 | pt_PT |
| oaire.citation.title | Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology | pt_PT |
| person.familyName | Peixoto | |
| person.familyName | Vieira da Silva | |
| person.familyName | Prudêncio | |
| person.givenName | Vanda | |
| person.givenName | Manuela | |
| person.givenName | Cristina | |
| person.identifier | 2545573 | |
| person.identifier | 1200571 | |
| person.identifier.ciencia-id | 8C1D-7FC0-8460 | |
| person.identifier.ciencia-id | C81E-F4EE-FADE | |
| person.identifier.orcid | 0000-0003-4883-3186 | |
| person.identifier.orcid | 0000-0003-1256-990X | |
| person.identifier.orcid | 0000-0002-9920-936X | |
| person.identifier.scopus-author-id | 57449894700 | |
| person.identifier.scopus-author-id | 6508057930 | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | conferenceObject | pt_PT |
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