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Publication
Biomimetic norfloxacin sensors made of molecularly-imprinted materials for potentiometric transduction
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Advisor(s)
Abstract(s)
A biomimetic sensor for norfloxacin is presented
that is based on host-guest interactions and potentiometric
transduction. The artificial host was imprinted into polymers
made from methacrylic acid and/or 2-vinyl pyridine. The
resulting particles were entrapped in a plasticized poly(vinyl
chloride) (PVC) matrix. The sensors exhibit near-Nernstian
response in steady state evaluations, and detection limits range
from 0.40 to 1.0 μgmL−1, respectively, and are independent
of pH values at between 2 and 6, and 8 and 11, respectively.
Good selectivity was observed over several potential
interferents. In flowing media, the sensors exhibit fast
response, a sensitivity of 68.2 mV per decade, a linear range
from 79 μM to 2.5 mM, a detection limit of 20 μgmL−1, and
a stable baseline. The sensors were successfully applied to
field monitoring of norfloxacin in fish samples, biological
samples, and pharmaceutical products
Description
Keywords
Norfloxacin Molecularly-imprinted sensors Potentiometry FIA Fish