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Design of an electrochemical genosensor for the BDNF gene polymorphism sequence detection using an enzymatic labelled DNA probe

2023-09-26Conference object Open access
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dc.contributor.authorCaldevilla, Renato
dc.contributor.authorMorais, Stephanie
dc.contributor.authorCarvalho, Serafim
dc.contributor.authorMedeiros, Rui
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorCruz, Agostinho
dc.contributor.authorSantos, Marlene
dc.contributor.authorBarroso, M. Fátima
dc.date.accessioned2023-10-26T15:49:10Z
dc.date.available2023-10-26T15:49:10Z
dc.date.issued2023-09-26
dc.description.abstractThe BDNF gene is associated with high degrees of variability in antidepressant treatments. The Val66Met polymorphism is widely known as a source of this variability, warranting growing interest in genotyping patients that undergo antidepressant treatment to better suit their needs. This paper reports on an electrochemical genosensing platform, based on gold electrodes, capable of detecting this polymorphism, through the use of synthetic enzymatic labelled DNA-probes for 2 different BDNF alleles. The sensor showed promising results, and its applicability to real samples is currently being tested.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCaldevilla, R., Santos, M., & Barroso, M. F. (2023). Design and Optimization of an Electrochemical Genosensing Platform for BDNF Val66Met Polymorphism Detection. Proceedings of Research and Practice in Allied and Environmental Health, 1(1), 36. https://doi.org/10.26537/prpaeh.v1i1.5174pt_PT
dc.identifier.doi10.3390/CSAC2023-14913pt_PT
dc.identifier.eissn2673-4591
dc.identifier.urihttp://hdl.handle.net/10400.22/23787
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThis work was funded by the Bilateral Cooperation FCT/CAPES 2018/2019 Processo 4.4.1.00 CAPES (CAPES-FCT2017484310 P 200.137.174.210) and the Ibero-American Program on Science and Technology (CYTED—GENOPSYSEN, P223RT0141) by the European Cooperation in Science and Technology (COST, ENOTTA-CA21147). Stephanie Morais (2023.02829.BD) is grateful to Fundação para a Ciência e a Tecnologia (FCT) and the European Union (EU) for her grant, financed by POPH-QREN-Tipologia 4.1-Formação Avançada, and funded by Fundo Social Europeu (FSE) and Ministério da Ciência, Tecnologia e Ensino Superior (MCTES). Maria Fatima Barroso thanks FCT for the FCT investigator grant (2020.03107. CEECIND).pt_PT
dc.relation.publisherversionhttps://sciforum.net/manuscripts/14913/manuscript.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectChronoamperometrypt_PT
dc.subjectDepressionpt_PT
dc.subjectElectrochemical genosensorpt_PT
dc.titleDesign of an electrochemical genosensor for the BDNF gene polymorphism sequence detection using an enzymatic labelled DNA probept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleEngineering proceedings 2nd International Electronic Conference on Chemical Sensors and Analytical Chemistry - CSAC 2023pt_PT
oaire.citation.volume1 (1)pt_PT
person.familyNameCruz
person.familyNameSantos
person.givenNameAgostinho
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0002-1157-8196
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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