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Comparative effectiveness of different probiotic delivery methods in oral Candidiasis: A Systematic Review

2025-12-18Artigo de investigação Acesso aberto
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dc.contributor.authorAshouritoustani, Reihaneh
dc.contributor.authorPinho, Cláudia
dc.contributor.authorOliveira, Ana Isabel
dc.contributor.authorBarros, Piedade
dc.contributor.authorCruz, Agostinho
dc.contributor.authorCruz, Agostinho
dc.contributor.authorGonçalves de Barros, Piedade Aurora
dc.date.accessioned2026-04-07T14:34:35Z
dc.date.available2026-04-07T14:34:35Z
dc.date.issued2025-12-18
dc.description.abstractOral candidiasis, mainly from Candida albicans, affects immunocompromised individuals, the elderly, and denture wearers. Probiotics offer immunomodulatory and microbiota-balancing benefits as potential antifungal alternatives. However, the comparative impact of different probiotic delivery methods remains inadequately explored. This systematic review evaluated the effectiveness of various probiotic delivery methods in reducing Candida colonization and clinical symptoms in oral candidiasis. Following PRISMA 2020 guidelines, a systematic review search across multiple databases included human clinical studies based (Medline, Web of Science, ScienceDirect, and ProQuest) on PICO criteria across all age groups. Outcomes assessed included Candida load, oral microbiota changes, symptom improvement, and disease recurrence. Of 297 articles screened, 10 met inclusion criteria. Delivery methods investigated included lozenges, capsules, yogurt, and cheese. Most studies reported reductions in Candida colony-forming units (CFUs) or prevalence, mainly for C. albicans and for non-albicans species, with probiotics such as Lactobacillus reuteri, L. rhamnosus, L. acidophilus, and Bifidobacterium strains. Some studies reported improved immunological markers, while symptom relief, especially when probiotics were combined with antifungals. Probiotics reduce Candida colonization and symptoms, with potential prolonged effects. They show promise as adjunctive therapies, but standardized, large-scale trials are needed for optimization.eng
dc.identifier.citationAshouritoustani, R., Pinho, C., Oliveira, A. I., Barros, P., & Cruz, A. (2025). Comparative Effectiveness of Different Probiotic Delivery Methods in Oral Candidiasis: A Systematic Review. Microorganisms, 13(12), 2883. https://doi.org/10.3390/microorganisms13122883
dc.identifier.doi10.3390/microorganisms13122883
dc.identifier.eissn2076-2607
dc.identifier.urihttp://hdl.handle.net/10400.22/32178
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationUID/50006/2025
dc.relation.hasversionhttps://www.mdpi.com/2076-2607/13/12/2883
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectOral candidiasis
dc.subjectProbiotic
dc.subjectMicrobiota
dc.subjectDelivery methods
dc.subjectFungal infections
dc.subjectEfficacy
dc.subjectCandida
dc.subjectAntifungal
dc.titleComparative effectiveness of different probiotic delivery methods in oral Candidiasis: A Systematic Revieweng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.titleMicroorganisms
oaire.citation.volume13
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCruz
person.familyNameGonçalves de Barros
person.givenNameAgostinho
person.givenNamePiedade Aurora
person.identifier.ciencia-idD210-6003-454B
person.identifier.orcid0000-0002-1157-8196
person.identifier.orcid0000-0002-2635-251X
person.identifier.scopus-author-id23981959400
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublicationa85b368a-8f13-45eb-a744-7c5810a38e2c
relation.isAuthorOfPublication.latestForDiscoveryd7ec3c5d-b3e0-4e34-8e24-4d1588876120

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