Is the MTHFR C677T polymorphism associated with obesity risk? – a meta-analysis.

Costa, J.; Oliveira, R.; Prudêncio, Cristina; Fernandes, Rúben

http://hdl.handle.net/10400.22/23777

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Abstract(s)

Overweight and obesity are a major worldwide health problem and its incidence is increasing every year. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and as a regulator of DNA methylation, synthesis, and repair. MTHFR gene is polymorphic at nucleotides 677 (C→T) and 1298 (A→C). MTHFR C677T polymorphism results in alloenzymes with decreased activity and several studies have pointed to association between the MTHFR C677T polymorphism and overweight/obesity risk.

Keywords

MTHFR C677T Polymorphism Obesity Risk

URI

http://hdl.handle.net/10400.22/23777

Citation

Costa, J., Oliveira, R., Prudêncio, C., & Fernandes, R. (2016). Is the MTHFR C677T polymorphism associated with obesity risk? – A meta-analysis. 8o Simpósio em Metabolismo da Faculdade de Medicina da Universidade do Porto, 11 (4) Revista Portuguesa de Diabetes, 181.