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Exploring bioactive properties of marine cyanobacteria Isolated from the Portuguese coast: high potential as a source of anticancer compounds

2014Journal article Open access
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dc.contributor.authorCosta, Margarida
dc.contributor.authorGarcia, Mónica
dc.contributor.authorCosta-Rodrigues, Joao
dc.contributor.authorCosta, Maria Sofia
dc.contributor.authorRibeiro, Maria João
dc.contributor.authorFernandes, Maria Helena
dc.contributor.authorBarros, Piedade
dc.contributor.authorBarreiro, Aldo
dc.contributor.authorVasconcelos, Vítor
dc.contributor.authorMartins, Rosario
dc.date.accessioned2014-01-10T11:25:23Z
dc.date.available2014-01-10T11:25:23Z
dc.date.issued2014
dc.description.abstractThe oceans remain a major source of natural compounds with potential in pharmacology. In particular, during the last few decades, marine cyanobacteria have been in focus as producers of interesting bioactive compounds, especially for the treatment of cancer. In this study, the anticancer potential of extracts from twenty eight marine cyanobacteria strains, belonging to the underexplored picoplanktonic genera, Cyanobium, Synechocystis and Synechococcus, and the filamentous genera, Nodosilinea, Leptolyngbya, Pseudanabaena and Romeria, were assessed in eight human tumor cell lines. First, a crude extract was obtained by dichloromethane:methanol extraction, and from it, three fractions were separated in a Si column chromatography. The crude extract and fractions were tested in eight human cancer cell lines for cell viability/toxicity, accessed with the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactic dehydrogenase release (LDH) assays. Eight point nine percent of the strains revealed strong cytotoxicity; 17.8% showed moderate cytotoxicity, and 14.3% assays showed low toxicity. The results obtained revealed that the studied genera of marine cyanobacteria are a promising source of novel compounds with potential anticancer activity and highlight the interest in also exploring the smaller filamentous and picoplanktonic genera of cyanobacteria.por
dc.description.sponsorshipThis research was supported by the European Regional Development Fund (ERDF) through the COMPETE - Operational Competitiveness Programme and national funds through FCT – Foundation for Science and Technology, under the project PTDC/MAR/102638/2008.por
dc.identifier.citationCosta, M., Garcia, M., Costa-Rodrigues, J., Costa, M. S., Ribeiro, M. J., Fernandes, M. H., Barros, P., Barreiro, A., Vasconcelos, V., & Martins, R. (2014). Exploring bioactive properties of marine cyanobacteria Isolated from the Portuguese coast: High potential as a source of anticancer compounds. Marine Drugs, Vol. 12(No 1), 98–114. https://doi.org/10.3390/md12010098
dc.identifier.doi10.3390/md12010098pt_PT
dc.identifier.issn1660-3397
dc.identifier.urihttp://hdl.handle.net/10400.22/3271
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPIpor
dc.subjectMarine cyanobacteriapor
dc.subjectNatural productspor
dc.subjectAnticancer potentialpor
dc.titleExploring bioactive properties of marine cyanobacteria Isolated from the Portuguese coast: high potential as a source of anticancer compoundspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage114por
oaire.citation.issueNº 1
oaire.citation.startPage98por
oaire.citation.titleMarine Drugspor
oaire.citation.volumeVol. 12por
person.familyNameCosta-Rodrigues
person.familyNameGonçalves de Barros
person.familyNameMartins
person.givenNameJoao
person.givenNamePiedade Aurora
person.givenNameRosario
person.identifier.ciencia-id7412-B006-2120
person.identifier.ciencia-idD210-6003-454B
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0003-1375-8067
person.identifier.orcid0000-0002-2635-251X
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id8558383400
person.identifier.scopus-author-id23981959400
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationce85cc8f-09f3-4c26-aeaf-6128971acf68
relation.isAuthorOfPublicationa85b368a-8f13-45eb-a744-7c5810a38e2c
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscoveryce85cc8f-09f3-4c26-aeaf-6128971acf68

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