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Role of pharmacogenomics in predicting antidepressant response and individualizing therapy

2015-11Conference object Open access
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dc.contributor.authorSantos, Marlene
dc.contributor.authorCarvalho, Serafim
dc.contributor.authorLima, Luís
dc.contributor.authorMota-Pereira, Jorge
dc.contributor.authorPimentel, Paulo
dc.contributor.authorMaia, Dulce
dc.contributor.authorCorreia, Diana
dc.contributor.authorGomes, Sofia
dc.contributor.authorCruz, Agostinho
dc.contributor.authorMedeiros, Rui
dc.date.accessioned2022-02-17T16:35:59Z
dc.date.available2022-02-17T16:35:59Z
dc.date.issued2015-11
dc.description.abstractMajor Depressive Disorder (MDD) is a highly prevalent chronic psychiatric condition with significant morbidity. Despite several antidepressants drugs (AD) available, a wide fraction of patients fail to respond, present relapse or display treatment resistant depression (TRD). Pharmacogenomics could help identify patients at risk of relapse or TRD and possibly have a direct impact on personalizing therapy. Additionally, recent studies suggested that immune activation and cytokines may be involved in depression, and its normalization occurs after antidepressant treatment. The proinflammatory cytokines interleukin-18 (IL-18) and IL-6 are less reported in depression, but considered to be relevant since they have been found to be increased in patients with depression.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationOliveira, A. I., Pinho, C., Fonte, P., Sarmento, B., & Dias, A. C. (2015). Development of polymeric nanoparticles containing neuroprotective compounds of Hypericum perforatum. In R. A. Silva, P. Baylina, F. Q. Vieira, C. Barrias, M. Rubim, T. Coelho, C. Prudêncio, & Â. Jesus (Eds.), II Congresso Internacional da Saúde Gaia Porto: Livro de Resumos (pp. 15-16). Escola Superior de Tecnologia da Saúde do Instituto Politécnico do Porto.pt_PT
dc.identifier.isbn978-989-20-6340-9
dc.identifier.urihttp://hdl.handle.net/10400.22/19991
dc.language.isoengpt_PT
dc.publisherESTSP-IPPpt_PT
dc.titleRole of pharmacogenomics in predicting antidepressant response and individualizing therapypt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceGaia Portopt_PT
oaire.citation.endPage17pt_PT
oaire.citation.startPage16pt_PT
oaire.citation.titleII Congresso Internacional da Saúde Gaia Porto: Livro de Resumospt_PT
person.familyNameSantos
person.familyNameOliveira Lima
person.familyNameCruz
person.givenNameMarlene
person.givenNameLuís Carlos
person.givenNameAgostinho
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.ciencia-id9F16-0E29-D9FC
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0001-8152-9237
person.identifier.orcid0000-0002-1157-8196
person.identifier.scopus-author-id57110502000
person.identifier.scopus-author-id23501978900
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublicationc6b00c1f-f4c9-4f4f-b291-17cf30b1e1f8
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication.latestForDiscoveryd7ec3c5d-b3e0-4e34-8e24-4d1588876120

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