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Advisor(s)
Abstract(s)
Hypericum perforatum is a perennial plant, with worldwide distribution, commonly
known as St. John’s wort. It has been used for centuries in traditional medicine
for the treatment of several disorders, such as minor burns, anxiety, and mild to
moderate depression. In the past years, its antidepressant properties have been
extensively studied. Despite that, other H. perforatum biological activities, as its
neuroprotective properties have also been evaluated. The present review aims to
provide a comprehensive summary of the main biologically active compounds of
H. perforatum, as for its chemistry, pharmacological activities, drug interactions and
adverse reactions and gather scattered information about its neuroprotective abilities. As
for this, it has been demonstrated that H. perforatum extracts and several of its major
molecular components have the ability to protect against toxic insults, either directly,
through neuroprotective mechanisms, or indirectly, through is antioxidant properties.
H. perforatum has therefore the potential to become an effective neuroprotective
therapeutic agent, despite further studies that need to be carried out.
Description
Keywords
Hypericum perforatum extracts compounds neuroprotection antioxidant activity