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Ketamine antidepressant properties: a systematic review of clinical trials

2022-11Book part Open access
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dc.contributor.authorFerreira, Diogo
dc.contributor.authorCruz, Agostinho
dc.contributor.authorSantos, Marlene
dc.date.accessioned2022-12-06T12:05:17Z
dc.date.available2022-12-06T12:05:17Z
dc.date.issued2022-11
dc.description.abstractKetamine has been used to provide a rapid and persistent antidepressant effect in patients with treatment-resistant depression. This drug reverses depressive symptoms by blocking N-methyl-D-Aspartate receptors, which causes a downstream effect on glutamatergic system. The main goal of this work consisted in a systematic review of the antidepressant and adverse events of Ketamine in patients with treatment-resistant depression. Keywords were defined with PICO´s strategy and systematic review was performed by using the PUBMED database. After inclusion and exclusion criteria, a total of 21 articles were included. Results showed a rapid antidepressant action from the resynchronization of neural circuits upon Ketamine use. However, this drug was also associated with several induced side-effects, including changes in blood pressure, dissociative symptoms, headache, nausea and vomits. Different routes of administration and ketamine metabolites may be used to help to overcome some of the induced side-effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFerreira, Diogo, Cruz, Agotinho, & Santos, M. (2022). Ketamine antidepressant properties: A systematic review of clinical trials. Em ATHENA Research Book, Volume 1 (Vol. 1, pp. 175–198). ATHENA European University, University of Maribor Press.pt_PT
dc.identifier.doi10.18690/um.3.2022pt_PT
dc.identifier.isbn978-961-286-659-4
dc.identifier.isbn978-961-286-658-7
dc.identifier.urihttp://hdl.handle.net/10400.22/21145
dc.language.isoengpt_PT
dc.publisherATHENA european university & University of Maribor Presspt_PT
dc.relation.publisherversionhttps://press.um.si/index.php/ump/catalog/book/735pt_PT
dc.subjectMajor depressive disorderpt_PT
dc.subjectTreatment-resistant depressionpt_PT
dc.subjectElectroconvulsive therapypt_PT
dc.subjectKetaminept_PT
dc.subjectAntidepressantpt_PT
dc.titleKetamine antidepressant properties: a systematic review of clinical trialspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage198pt_PT
oaire.citation.startPage175pt_PT
oaire.citation.titleATHENA Research Book, Volume 1pt_PT
oaire.citation.volume1pt_PT
person.familyNameCruz
person.familyNameSantos
person.givenNameAgostinho
person.givenNameMarlene
person.identifier1508370
person.identifier.ciencia-id8311-B967-31C4
person.identifier.orcid0000-0002-1157-8196
person.identifier.orcid0000-0001-5020-5942
person.identifier.scopus-author-id57110502000
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationd7ec3c5d-b3e0-4e34-8e24-4d1588876120
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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