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Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer

2016Journal article Open access
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dc.contributor.authorAlmeida-Rios, Diogo
dc.contributor.authorPinho dos Santos Graça, Maria Inês
dc.contributor.authorQuintela Vieira, Ana Filipa
dc.contributor.authorRamalho-Carvalho, João
dc.contributor.authorPereira-Silva, Eva
dc.contributor.authorMartins, Ana Teresa
dc.contributor.authorOliveira, Jorge
dc.contributor.authorGonçalves, Céline S.
dc.contributor.authorCosta, Bruno M.
dc.contributor.authorHenrique, Rui
dc.contributor.authorJerónimo, Carmen
dc.date.accessioned2019-05-20T13:07:45Z
dc.date.available2019-05-20T13:07:45Z
dc.date.issued2016
dc.description.abstractProstate cancer (PCa) is a major cause of morbidity and mortality. Until now the specific role of histone methyltransferases (HMTs) deregulated expression/activity in PCa is poorly understood. Herein we aimed to uncover the potential oncogenic role of PRMT6 in prostate carcinogenesis. PRMT6 overexpression was confirmed in PCa, at transcript and protein level. Stable PRMT6 knockdown in PC-3 cells attenuated malignant phenotype, increasing apoptosis and decreasing cell viability, migration and invasion. PRMT6 silencing was associated with decreased H3R2me2a levels and increased MLL and SMYD3 expression. PRMT6 silencing increased p21, p27 and CD44 and decreased MMP-9 expression and was associated with PI3K/AKT/mTOR downregulation and increased AR signaling pathway. In Sh-PRMT6 cells, AR restored expression might re-sensitized cells to androgen deprivation therapy, impacting in clinical management of castration-resistant PCa (CRPC). PRMT6 plays an oncogenic role in PCa and predicts for more clinically aggressive disease, constituting a potential target for patients with CRPC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlmeida-Rios, D., Graça, I., Vieira, F. Q., Ramalho-Carvalho, J., Pereira-Silva, E., Martins, A. T., Oliveira, J., Gonçalves, C. S., Costa, B. M., Henrique, R., & Jerónimo, C. (2016). Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer. Oncotarget, 7(33), 53018–53028. https://doi.org/10.18632/oncotarget.10061
dc.identifier.doi10.18632/oncotarget.10061pt_PT
dc.identifier.other1949-2553
dc.identifier.urihttp://hdl.handle.net/10400.22/13746
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCI-IPOP-BPD/UID/DTP/00776/2013pt_PT
dc.relationFP7-HEALTH-F5-2009-241783pt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5288165/pt_PT
dc.subjectAged, 80 and overpt_PT
dc.subjectCarcinogenesispt_PT
dc.subjectCell Line, Tumorpt_PT
dc.subjectGene Expression Regulation, Neoplasticpt_PT
dc.subjectHumanspt_PT
dc.subjectKaplan-Meier Estimatept_PT
dc.subjectMatrix Metalloproteinase 9pt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectNuclear Proteinspt_PT
dc.subjectOncogenespt_PT
dc.subjectProstatic Neoplasmspt_PT
dc.subjectProstatic Neoplasms, Castration-Resistantpt_PT
dc.subjectProtein-Arginine N-Methyltransferasespt_PT
dc.subjectRNA Interferencept_PT
dc.subjectReceptors, Androgenpt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectmalept_PT
dc.titleHistone methyltransferase PRMT6 plays an oncogenic role of in prostate cancerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F70564%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F71293%2F2010/PT
oaire.citation.endPage53028pt_PT
oaire.citation.issue33pt_PT
oaire.citation.startPage53018pt_PT
oaire.citation.titleOncotargetpt_PT
oaire.citation.volume7pt_PT
oaire.fundingStreamSFRH
oaire.fundingStreamSFRH
person.familyNamePinho dos Santos Graça
person.familyNameQuintela Vieira
person.givenNameMaria Inês
person.givenNameAna Filipa
person.identifier.orcid0000-0003-1383-4242
person.identifier.orcid0000-0003-0130-7664
person.identifier.scopus-author-id6505981373
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8316e6ce-cc0a-41e6-90ab-910c93868670
relation.isAuthorOfPublication47123d10-a0ed-47cc-a751-721489a13446
relation.isAuthorOfPublication.latestForDiscovery47123d10-a0ed-47cc-a751-721489a13446
relation.isProjectOfPublication98907a9c-a835-4111-8335-8022ee7d4fef
relation.isProjectOfPublicationa7c6b45b-cce6-48c1-adc0-0f12c04cad73
relation.isProjectOfPublication.latestForDiscovery98907a9c-a835-4111-8335-8022ee7d4fef

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