Repository logo
 
Publication

The carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactate

2017Journal article Open access
Simple item page
dc.contributor.authorAlves, Rosana
dc.contributor.authorMota, Sandra
dc.contributor.authorSilva, Sónia
dc.contributor.authorF. Rodrigues, Célia
dc.contributor.authorP. Brown, Alistair J.
dc.contributor.authorHenriques, Mariana
dc.contributor.authorCasal, Margarida
dc.contributor.authorPaiva, Sandra
dc.date.accessioned2019-07-29T16:19:56Z
dc.date.available2019-07-29T16:19:56Z
dc.date.issued2017
dc.description.abstractCandida albicans has the ability to adapt to different host niches, often glucose-limited but rich in alternative carbon sources. In these glucose-poor microenvironments, this pathogen expresses JEN1 and JEN2 genes, encoding carboxylate transporters, which are important in the early stages of infection. This work investigated how host microenvironments, in particular acidic containing lactic acid, affect C. albicans biofilm formation and antifungal drug resistance. Multiple components of the extracellular matrix were also analysed, including their impact on antifungal drug resistance, and the involvement of both Jen1 and Jen2 in this process. The results show that growth on lactate affects biofilm formation, morphology and susceptibility to fluconazole and that both Jen1 and Jen2 might play a role in these processes. These results support the view that the adaptation of Candida cells to the carbon source present in the host niches affects their pathogenicity.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1080/08927014.2017.1392514pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14499
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationPTDC/BIAMIC/5184/2014pt_PT
dc.relationSTUDY OF THE MECHANISMS OF TRANSPORT AND REGULATION OF CARBOXYLIC ACIDS IN CANDIDA ALBICANS AND CANDIDA GLABRATA
dc.relationFunction and regulation of Candida albicans and C. glabata carboxylic acid transporters and thei role in biofilm formation, antifungal drug resistance and phagocytosis
dc.relationPOCI-01-0145-FEDER-007569pt_PT
dc.relationNORTE-01-0145-FEDER-000004pt_PT
dc.relation.publisherversionhttps://www.tandfonline.com/doi/full/10.1080/08927014.2017.1392514pt_PT
dc.subjectAdaptation, Physiologicalpt_PT
dc.subjectAntifungal Agentspt_PT
dc.subjectBiofilmspt_PT
dc.subjectBiofoulingpt_PT
dc.subjectCandida albicanspt_PT
dc.subjectCarboxylic Acidspt_PT
dc.subjectCellular Microenvironmentpt_PT
dc.subjectDrug Resistance, Fungalpt_PT
dc.subjectFluconazolept_PT
dc.subjectFungal Proteinspt_PT
dc.subjectGlucosept_PT
dc.subjectLactic Acidpt_PT
dc.subjectMonocarboxylic Acid Transporterspt_PT
dc.titleThe carboxylic acid transporters Jen1 and Jen2 affect the architecture and fluconazole susceptibility of Candida albicans biofilm in the presence of lactatept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSTUDY OF THE MECHANISMS OF TRANSPORT AND REGULATION OF CARBOXYLIC ACIDS IN CANDIDA ALBICANS AND CANDIDA GLABRATA
oaire.awardTitleFunction and regulation of Candida albicans and C. glabata carboxylic acid transporters and thei role in biofilm formation, antifungal drug resistance and phagocytosis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F74790%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F93078%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/PD%2FBD%2F113813%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIA%2F04050%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FBIO%2F04469%2F2013/PT
oaire.citation.endPage954pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage943pt_PT
oaire.citation.titleBiofoulingpt_PT
oaire.citation.volume33pt_PT
oaire.fundingStreamSFRH
oaire.fundingStreamPOR_NORTE
oaire.fundingStream5876
oaire.fundingStream5876
person.familyNameMota
person.givenNameSandra
person.identifier.ciencia-id0A19-207B-6C63
person.identifier.orcid0000-0002-2803-7230
person.identifier.scopus-author-id6603695681
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf73a5c8e-1621-435f-a34f-c3cc83924875
relation.isAuthorOfPublication.latestForDiscoveryf73a5c8e-1621-435f-a34f-c3cc83924875
relation.isProjectOfPublicationf0ed27be-e8ca-4f08-b84c-74473934fbe3
relation.isProjectOfPublicationeb2d3c27-adea-4700-bc50-31f09baa6678
relation.isProjectOfPublication2fb5cdb7-87c1-4385-9269-f28501463447
relation.isProjectOfPublication34715e6f-7ccc-439f-9322-558d880085d0
relation.isProjectOfPublicatione32e2560-63f1-48c6-9d01-9064301c0d5e
relation.isProjectOfPublication.latestForDiscovery34715e6f-7ccc-439f-9322-558d880085d0

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ART_SandraMota_2017.pdf
Size:
2.15 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESS - CISA - Artigos
ESS - ACSP - Artigos