Publication
Flow injection electrochemical determination of apomorphine
| dc.contributor.author | Garrido, Jorge | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.contributor.author | Borges, Fernanda | |
| dc.contributor.author | Macedo, Tice R. A. | |
| dc.contributor.author | Oliveira-Brett, A. M. | |
| dc.date.accessioned | 2013-11-27T12:19:38Z | |
| dc.date.available | 2013-11-27T12:19:38Z | |
| dc.date.issued | 2003 | |
| dc.description.abstract | Few analytical methods are currently available for determination of apomorphine, the active substance of a new oral formulation used in the treatment of erectile dysfunction. In this way a flow injection electrochemical method (FIA-EC) was developed for its quantification and applied to pharmaceutical dosage forms. Based in previous findings regarding the stability of apomorphine in borate buffer and after optimization of several analytical parameters a single channel flow injection manifold was set up that enables the determination of this drug over the concentration range of 3 to 16 µmol L-1 with a detection limit of 0.5 µmol L-1 at a sampling rateof 90 h-1. The simplicity and rapidity of the FIA-EC method used, its reproducibility and sensitivity make it suitable for quality control of pharmaceutical preparations of apomorphine intended for clinical use and research. | por |
| dc.identifier.doi | 10.1081/AL-120023711 | pt_PT |
| dc.identifier.issn | 0003-2719 | |
| dc.identifier.issn | 1532-236X | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/2988 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Taylor & Francis | por |
| dc.relation.ispartofseries | Analytical Letters; Vol. 36, Issue 10 | |
| dc.relation.publisherversion | http://www.tandfonline.com/doi/abs/10.1081/AL-120023711#.Uon930r6Q24 | por |
| dc.subject | Apomorphine | por |
| dc.subject | Electrochemical detection | por |
| dc.subject | Flow injection | por |
| dc.title | Flow injection electrochemical determination of apomorphine | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 2210 | por |
| oaire.citation.startPage | 2199 | por |
| oaire.citation.title | Analytical Letters | por |
| oaire.citation.volume | 36 | por |
| person.familyName | Garrido | |
| person.familyName | Delerue-Matos | |
| person.givenName | Jorge | |
| person.givenName | Cristina | |
| person.identifier.ciencia-id | 9A1A-43FB-5C27 | |
| person.identifier.orcid | 0000-0001-8981-231X | |
| person.identifier.orcid | 0000-0002-3924-776X | |
| person.identifier.rid | D-4990-2013 | |
| person.identifier.scopus-author-id | 7202779733 | |
| person.identifier.scopus-author-id | 6603741848 | |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | f548e711-c68e-4c49-9471-9923c047116d | |
| relation.isAuthorOfPublication | 09f6a7bd-2f15-42b0-adc5-04bd22210519 | |
| relation.isAuthorOfPublication.latestForDiscovery | f548e711-c68e-4c49-9471-9923c047116d |