A carregar...
Publicação
Flow injection electrochemical determination of apomorphine
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 96.21 KB | Adobe PDF |
Orientador(es)
Resumo(s)
Few analytical methods are currently available for determination
of apomorphine, the active substance of a new oral formulation
used in the treatment of erectile dysfunction. In this way a flow injection electrochemical method (FIA-EC) was developed for its
quantification and applied to pharmaceutical dosage forms. Based
in previous findings regarding the stability of apomorphine in borate
buffer and after optimization of several analytical parameters a single
channel flow injection manifold was set up that enables the determination
of this drug over the concentration range of 3 to 16 µmol L-1
with a detection limit of 0.5 µmol L-1 at a sampling rateof 90 h-1.
The simplicity and rapidity of the FIA-EC method used, its reproducibility
and sensitivity make it suitable for quality control of
pharmaceutical preparations of apomorphine intended for clinical
use and research.
Descrição
Palavras-chave
Apomorphine Electrochemical detection Flow injection
Contexto Educativo
Citação
Editora
Taylor & Francis