Publication
Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitine
| dc.contributor.author | Amorim, Manuela | |
| dc.contributor.author | Silva, Ana Isabel | |
| dc.contributor.author | Alves, Cecília Juliana | |
| dc.contributor.author | Monteiro, Pedro R. | |
| dc.contributor.author | Magalhães, Ana | |
| dc.contributor.author | Summavielle, Teresa | |
| dc.date.accessioned | 2025-07-08T08:44:45Z | |
| dc.date.available | 2025-07-08T08:44:45Z | |
| dc.date.issued | 2019-10 | |
| dc.description.abstract | Olanzapine (Olz) have been reported to promote higher risk for metabolic side-effects, such as obesity, dyslipidemia, and diabetes. Moreover/On the other hand, acetyl-L-carnitine (ALC) has been reported to improve homeostasis. This study aims to explore if ALC could improve metabolic homeostasis due to Olz effects on a rodent model. We investigated the effects of subchronic administration of Olz and with the addition of ALC on body weight gain and glucose metabolism in Wistar rats. Mid-term Olz exposure in rats significantly increases blood glucose levels in fasting and after the overload of glucose compared to the sali-ne-treated group (p<0.05). However, in rats mid-term treated with olanzapine plus acetyl-L-carnitine had no significant differences in fasting blood glucose levels compared to the saline-treated group. The findings suggest that ALC added to Olz treatment appeared to be effective to improve glucose metabolism during olanzapine subchronic treatment. | por |
| dc.identifier.citation | Amorim, M., Silva, A. I., Alves, C. J., Monteiro, P. R., Magalhães, A., & Summavielle, T. (2019). Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitine. 11o Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto - Revista Portuguesa de Diabetes, 14(4). http://www.revportdiabetes.com/wp-content/uploads/2020/02/RPD-DEZ-2019-Revista-Nacional-págs-164-175.pdf | |
| dc.identifier.uri | http://hdl.handle.net/10400.22/30211 | |
| dc.language.iso | eng | |
| dc.peerreviewed | n/a | |
| dc.publisher | SPD - Sociedade Portuguesa de Diabetologia | |
| dc.relation.hasversion | http://www.revportdiabetes.com/wp-content/uploads/2020/02/RPD-DEZ-2019-Revista-Nacional-págs-164-175.pdf | |
| dc.rights.uri | N/A | |
| dc.subject | Olanzapine | |
| dc.subject | Acetyl-L-carnitine | |
| dc.subject | Glucose homeostasis | |
| dc.subject | Locomotor activity | |
| dc.title | Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitine | por |
| dc.type | conference poster | |
| dspace.entity.type | Publication | |
| oaire.citation.conferenceDate | 2019-10 | |
| oaire.citation.endPage | 175 | |
| oaire.citation.issue | 4 | |
| oaire.citation.startPage | 174 | |
| oaire.citation.title | 11º Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto - Revista Portuguesa de Diabetes | |
| oaire.citation.volume | 14 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |