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Publication
Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitine
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Advisor(s)
Abstract(s)
Olanzapine (Olz) have been reported to promote higher risk for metabolic side-effects, such as obesity, dyslipidemia, and diabetes. Moreover/On the other hand, acetyl-L-carnitine (ALC) has been reported to improve homeostasis. This study aims to explore if ALC could improve metabolic homeostasis due to Olz effects on a rodent model. We investigated the effects of subchronic administration of Olz and with the addition of ALC on body weight gain and glucose metabolism in Wistar rats. Mid-term Olz exposure in rats significantly increases blood glucose levels in fasting and after the overload of glucose compared to the sali-ne-treated group (p<0.05). However, in rats mid-term treated with olanzapine plus acetyl-L-carnitine had no significant differences in fasting blood glucose levels compared to the saline-treated group. The findings suggest that ALC added to Olz treatment appeared to be effective to improve glucose metabolism during olanzapine subchronic treatment.
Description
Keywords
Olanzapine Acetyl-L-carnitine Glucose homeostasis Locomotor activity
Citation
Amorim, M., Silva, A. I., Alves, C. J., Monteiro, P. R., Magalhães, A., & Summavielle, T. (2019). Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitine. 11o Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto - Revista Portuguesa de Diabetes, 14(4). http://www.revportdiabetes.com/wp-content/uploads/2020/02/RPD-DEZ-2019-Revista-Nacional-págs-164-175.pdf
Publisher
SPD - Sociedade Portuguesa de Diabetologia
CC License
Without CC licence