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3D vs 2D Cell Cultures in the Evaluation of Radiobiological Effects of Exposition to Low Doses - Medical Imaging Levels - of Ionizing Radiation

2011-10-15Conference object Open access
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dc.contributor.authorCosta, Pedro
dc.contributor.authorCaires, Hugo
dc.contributor.authorLemos, Joana
dc.contributor.authorCunha, Lídia
dc.contributor.authorBravo, Joana
dc.contributor.authorBravo, Isabel
dc.contributor.authorSilva, Regina
dc.contributor.authorSummavielle, Teresa
dc.contributor.authorMetello, Luís F.
dc.date.accessioned2015-01-30T14:45:08Z
dc.date.available2015-01-30T14:45:08Z
dc.date.issued2011-10-15
dc.description.abstractPretending to develop advanced biological models to study biological effects of low doses of ionizing radiation and following the actual policies on Animal Sciences, based on 3 R’s Rule (to Reduce, Refine and Replace) – that limits as much as possible the application of animal models – scientific research using cellular models is constantly increasing. Nevertheless, the intrinsic limitations of actual cellular models quite often had been recognized on a significant number of papers pointing a significant number of non-concordances between results obtained using in vitro and in vivo studies. Actually, an increasing number of authors admit that three-dimensional cell culture (and spheroid cell culture in particular) could represent an interesting solution and a step further on use of cellular models. The work here to be presented reflects the first phase on the use of this methodology on the study, evaluation and quantification of cellular effects of low doses – starting on medical imaging level - of exposition to ionizing radiation.en
dc.identifier.urihttp://hdl.handle.net/10400.22/5548
dc.language.isoengpor
dc.peerreviewedyespor
dc.title3D vs 2D Cell Cultures in the Evaluation of Radiobiological Effects of Exposition to Low Doses - Medical Imaging Levels - of Ionizing Radiationpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceInternationalpor
oaire.citation.titleBirmingham 2011 - Annual Congress of the European Association of Nuclear Medicinepor
person.familyNameLemos
person.familyNameBravo
person.familyNameSilva
person.familyNameSummavielle
person.givenNameJoana
person.givenNameJoana
person.givenNameRegina
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-id3F11-3268-F06A
person.identifier.ciencia-idAA15-F362-062E
person.identifier.ciencia-id871B-D071-507D
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0002-5734-7166
person.identifier.orcid0000-0002-8403-7235
person.identifier.orcid0000-0002-8373-1217
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6603092949
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication04aa6dfe-65b2-4606-877b-3ebd15e78111
relation.isAuthorOfPublication617f0f54-58dd-45b8-a90f-177187cd197e
relation.isAuthorOfPublication60471846-7876-49e1-b405-6ffe770795ae
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery617f0f54-58dd-45b8-a90f-177187cd197e

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