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Very long-term effects of chronic cocaine on anxiety and stress

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dc.contributor.authorAlves, C.J.
dc.contributor.authorMagalhães, A.
dc.contributor.authorMonteiro, Pedro
dc.contributor.authorSummavielle, Teresa
dc.date.accessioned2019-07-11T09:42:07Z
dc.date.available2019-07-11T09:42:07Z
dc.date.issued2017
dc.description.abstractHigh anxiety levels and heightened stress are important factors for cocaine maintenance, reinforcing, and relapse. Chronic cocaine is known to result in a high prevalence of anxiety disorders. However, anxiety and poor stress coping are also relevant factors to the onset of cocaine use. Consequently, there is a strong association between cocaine, anxiety, and stress, which results from impaired functioning of the mesocorticolimbic system, and deregulation of the hypothalamus–pituitary–adrenal axis. Here, we review the long-term effects of chronic cocaine on anxiety and stress both in clinical and preclinical reports. Adolescence in particular is a developmental period of high prevalence of anxiety disorders, where impaired response to stressors appears as a relevant factor for drug vulnerability and experimentation. At withdrawal, heightened states of anxiety are also common, acting as relapse promoters. Improved understanding of how anxiety and stress evolve in response to chronic cocaine may contribute to more comprehensive therapeutic approaches.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves, C. J., Magalhães, A., Monteiro, P. R., & Summavielle, T. (2017). Chapter 35—Very Long-Term Effects of Chronic Cocaine on Anxiety and Stress. Em V. R. Preedy (Ed.), The Neuroscience of Cocaine (pp. 343–352). Academic Press. https://doi.org/10.1016/B978-0-12-803750-8.00035-X
dc.identifier.doi10.1016/B978-0-12-803750-8.00035-Xpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14327
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/B978012803750800035Xpt_PT
dc.subjectAnxietypt_PT
dc.subjectstresspt_PT
dc.subjectCortisolpt_PT
dc.subjectAdolescentpt_PT
dc.titleVery long-term effects of chronic cocaine on anxiety and stresspt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage352pt_PT
oaire.citation.startPage343pt_PT
oaire.citation.titleThe Neuroscience of Cocaine: Mechanisms and Treatmentpt_PT
person.familyNameMonteiro
person.familyNameSummavielle
person.givenNamePedro
person.givenNameTeresa
person.identifier677706
person.identifier.ciencia-id2414-4468-928B
person.identifier.ciencia-idC41E-0816-5C85
person.identifier.orcid0000-0002-3991-9191
person.identifier.orcid0000-0003-2548-6281
person.identifier.ridC-9776-2012
person.identifier.scopus-author-id6504494827
person.identifier.scopus-author-id6603092949
rcaap.rightsclosedAccesspt_PT
rcaap.typebookPartpt_PT
relation.isAuthorOfPublicationfae8b5b3-db39-4d56-a2b1-2db0388279b9
relation.isAuthorOfPublication207ee2de-85a0-4144-9e7e-b376c600e065
relation.isAuthorOfPublication.latestForDiscovery207ee2de-85a0-4144-9e7e-b376c600e065

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