Publication
Development of electrochemical methods for determination of tramadol - analytical application to pharmaceutical dosage forms
| dc.contributor.author | Garrido, E. Manuela | |
| dc.contributor.author | Garrido, Jorge | |
| dc.contributor.author | Borges, F. | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.date.accessioned | 2013-11-25T15:43:22Z | |
| dc.date.available | 2013-11-25T15:43:22Z | |
| dc.date.issued | 2003 | |
| dc.description.abstract | A square-wave voltammetric (SWV) method and a flow injection analysis system with amperometric detection were developed for the determination of tramadol hydrochloride. The SWV method enables the determination of tramadol over the concentration range of 15-75 µM with a detection limit of 2.2 µM. Tramadol could be determined in concentrations between 9 and 50 µM at a sampling rate of 90 h-1, with a detection limit of 1.7 µM using the flow injection system. The electrochemical methods developed were successfully applied to the determination of tramadol in pharmaceutical dosage forms, without any pre-treatment of the samples. Recovery trials were performed to assess the accuracy of the results; the values were between 97 and 102% for both methods. | por |
| dc.identifier.doi | 10.1016/S0731-7085(03)00199-7 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.22/2948 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.relation.ispartofseries | Journal of Pharmaceutical and Biomedical Analysis; Vol. 32, Issue 4-5 | |
| dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0731708503001997# | por |
| dc.subject | Tramadol | por |
| dc.subject | Square-wave voltammetry | por |
| dc.subject | FIA | por |
| dc.subject | Electrochemical detection | por |
| dc.title | Development of electrochemical methods for determination of tramadol - analytical application to pharmaceutical dosage forms | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 981 | por |
| oaire.citation.startPage | 975 | por |
| oaire.citation.title | Journal of Pharmaceutical and Biomedical Analysis | por |
| oaire.citation.volume | 32 | por |
| person.familyName | Garrido | |
| person.familyName | Delerue-Matos | |
| person.givenName | Jorge | |
| person.givenName | Cristina | |
| person.identifier.ciencia-id | 9A1A-43FB-5C27 | |
| person.identifier.orcid | 0000-0001-8981-231X | |
| person.identifier.orcid | 0000-0002-3924-776X | |
| person.identifier.rid | D-4990-2013 | |
| person.identifier.scopus-author-id | 7202779733 | |
| person.identifier.scopus-author-id | 6603741848 | |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |
| relation.isAuthorOfPublication | f548e711-c68e-4c49-9471-9923c047116d | |
| relation.isAuthorOfPublication | 09f6a7bd-2f15-42b0-adc5-04bd22210519 | |
| relation.isAuthorOfPublication.latestForDiscovery | f548e711-c68e-4c49-9471-9923c047116d |