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Advisor(s)
Abstract(s)
A square-wave voltammetric (SWV) method and a flow injection analysis system with amperometric detection were
developed for the determination of tramadol hydrochloride. The SWV method enables the determination of tramadol
over the concentration range of 15-75 µM with a detection limit of 2.2 µM. Tramadol could be determined in
concentrations between 9 and 50 µM at a sampling rate of 90 h-1, with a detection limit of 1.7 µM using the flow
injection system. The electrochemical methods developed were successfully applied to the determination of tramadol in
pharmaceutical dosage forms, without any pre-treatment of the samples. Recovery trials were performed to assess the
accuracy of the results; the values were between 97 and 102% for both methods.
Description
Keywords
Tramadol Square-wave voltammetry FIA Electrochemical detection
Citation
Publisher
Elsevier