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Molecular impact of [C16Pyr][Amp] treatment on breast and prostate cancer cell lines

2019-04Conference object Open access
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dc.contributor.authorQuintela Vieira, Ana Filipa
dc.contributor.authorMarques-Magalhães, Ângela
dc.contributor.authorMiranda-Gonçalves, Vera
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorJerónimo, Carmen
dc.contributor.authorSilva, Regina
dc.date.accessioned2023-02-13T18:24:34Z
dc.date.available2023-02-13T18:24:34Z
dc.date.issued2019-04
dc.description.abstractProstate Cancer (PCa) and Breast Cancer (BCa) are the leading causes of cancer morbidity and mortality, worldwide, when diagnosed in advanced stages of the disease. Currently available therapies have limited curative effect, leading to the progression to highly aggressive hormone-resistant phenotypes. Thus, the development of new anti-tumor agents becomes imperative. Ionic liquids are organic salts with anti-neoplastic activity and have been studied in the pharmaceutical industry. Previous work of our team demonstrated that the ionic liquid [C16Pyr][Amp] has significant anti-tumor properties in PCa and BCa cell lines. However, the main cellular pathways affected were not characterized. Therefore, the aim of this work was to explore the molecular impact of [C16Pyr][Amp] treatment in order to identify relevant genes that have altered expression upon treatment and that can justify the anti-cancer effect observed in the in vitro assays.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationVieira, Filipa Quintela, Marques-Magalhães, Miranda-Gonçalves, V., Ferraz, Ricardo., Prudêncio, Cristina., Jerónimo, C., & Silva, R. A. (2019, abril). Molecular impact of [C16Pyr][Amp] treatment on breast and prostate cancer cell lines [Comunicação oral]. Workshop on R&D projects: proceedings, Porto.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/22259
dc.language.isoengpt_PT
dc.subjectBreast cancerpt_PT
dc.subjectProstate cancerpt_PT
dc.subjectSynthetic compoundspt_PT
dc.subjectMolecular analysispt_PT
dc.titleMolecular impact of [C16Pyr][Amp] treatment on breast and prostate cancer cell linespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
oaire.citation.endPage8pt_PT
oaire.citation.startPage7pt_PT
oaire.citation.titleWorkshop on R&D projects: proceedingspt_PT
person.familyNameQuintela Vieira
person.familyNameMagalhães
person.familyNameFerraz
person.familyNamePrudêncio
person.familyNameSilva
person.givenNameAna Filipa
person.givenNameÂngela
person.givenNameRicardo
person.givenNameCristina
person.givenNameRegina
person.identifier619581
person.identifier1200571
person.identifier.ciencia-idDF17-0107-A62A
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id871B-D071-507D
person.identifier.orcid0000-0003-0130-7664
person.identifier.orcid0000-0001-8961-5324
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0002-8373-1217
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id57201645537
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication47123d10-a0ed-47cc-a751-721489a13446
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relation.isAuthorOfPublication.latestForDiscovery47123d10-a0ed-47cc-a751-721489a13446

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