Potential drug interactions between oral antineoplastic agents and opioid analgesics

Antunes, Cláudia; Carvalho, Daniel; Jesus, Ângelo

Publication

Potential drug interactions between oral antineoplastic agents and opioid analgesics

2022-11Book part

dc.contributor.author	Antunes, Cláudia
dc.contributor.author	Carvalho, Daniel
dc.contributor.author	Jesus, Ângelo
dc.date.accessioned	2022-12-06T12:12:13Z
dc.date.available	2022-12-06T12:12:13Z
dc.date.issued	2022-11
dc.description.abstract	Oral antineoplastic drugs use has been gaining more importance due to its multiple benefits and the introduction of new molecules with new mechanisms of action. Opioids are often conjugated with antineoplastic therapy, however, this association brings possible drug interactions. Cytochrome P450 is responsible for the metabolization of a great part of drugs on the market. Identifying, explaining, and assessing the severity of possible drug interactions between oral antineoplastic agents and opioid analgesics were the aims of this investigation. A cross-sectional observational study was developed. Drugs selected in FHNM, were combined one by one in the Micromedex database. Twenty-three interactions were found with different types of grades of evidence and severity, and six were explained. Procarbazine was the oral antineoplastic with the highest number of possible interactions, while the opioid was buprenorphine. It’s important to monitor drug interactions in cancer patients considering the serious consequences that may arise from these.	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Antunes, Cláudia, Carvalho, Daniel, & Jesus, Ângelo. (2022). Potential drug interactions between oral antineoplastic agents and opioid analgesics. Em ATHENA Research Book, Volume 1 (Vol. 1, pp. 199–213). ATHENA European University, University of Maribor Press.	pt_PT
dc.identifier.doi	10.18690/um.3.2022	pt_PT
dc.identifier.isbn	978-961-286-659-4
dc.identifier.isbn	978-961-286-658-7
dc.identifier.uri	http://hdl.handle.net/10400.22/21147
dc.language.iso	eng	pt_PT
dc.publisher	ATHENA European University & University of Maribor Press	pt_PT
dc.relation.publisherversion	https://press.um.si/index.php/ump/catalog/book/735	pt_PT
dc.subject	Antineoplastic agents	pt_PT
dc.subject	Opioid analgesics	pt_PT
dc.subject	Drug interactions	pt_PT
dc.subject	Cancer therapy	pt_PT
dc.subject	Pain management	pt_PT
dc.title	Potential drug interactions between oral antineoplastic agents and opioid analgesics	pt_PT
dc.type	book part
dspace.entity.type	Publication
oaire.citation.endPage	213	pt_PT
oaire.citation.startPage	199	pt_PT
oaire.citation.title	ATHENA Research Book, Volume 1	pt_PT
oaire.citation.volume	1	pt_PT
person.familyName	Jesus
person.givenName	Ângelo
person.identifier.ciencia-id	A91F-3585-4F42
person.identifier.orcid	0000-0003-3972-8253
person.identifier.rid	A-4404-2012
person.identifier.scopus-author-id	56153841300
rcaap.rights	closedAccess	pt_PT
rcaap.type	bookPart	pt_PT
relation.isAuthorOfPublication	1cbff3da-9800-4bd7-8d84-fd8d9ca819b2
relation.isAuthorOfPublication.latestForDiscovery	1cbff3da-9800-4bd7-8d84-fd8d9ca819b2