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Abstract(s)
Squamous cell carcinoma (SCC) is a malignant, poorly differentiated neuroendocrine neoplasm. SCC is the common form of bladder cancer in rural Africa where S. haematobium is prevalent. In contrast, the majority of bladder cancer in developing countries and regions not endemic for urogenital schistosomiasis is transitional cell carcinoma (TCC) that arises from the transitional epithelium lining of the bladder. The parasite eggs trapped in the bladder wall release antigens and other metabolites (presumably evolved to expedite egress to the urine, and hence to the external environment). However, the phenomenon leads to haematuria and to chronic inflammation, in turn increasing risk of SCC of the bladder. In addition to the hormone- -like effects of the parasite estradiol-related molecules on the endocrine and immune system of the host, in relation to cancer initiation metabolites of estrogens can be also considered as carcinogenic chemicals.
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Citation
Rita R., Luis C., Soares R., Fernandes R., & Botelho M.C. (2019). Pathways of estrogen metabolism underlying the association between Schistosoma haematobium and bladder cancer. 10º Simpósio de Metabolismo da Faculdade de Medicina da Universidade do Porto – Palestras, Comunicações Orais e Posters, 38.