Helthcare professionals´ knowledge, attitudes and practices in radiopharmaceuticals pharmacovigilance: contributions to the development and validation of a questionnaire

Arruda, Nathalia Maciel de

http://hdl.handle.net/10400.22/29610

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Authors

Arruda, Nathalia Maciel de

Advisor(s)

Jesus, Ângelo

Abstract(s)

Pharmacovigilance monitors the safety of medications, vacines, and biological substances, promoting their rational use and preventing adversa reactions. Spontaneous reporting of ADR sis the primary method of pharmacovigilance, generating alerts to minimize risks. Despite its importance, these events are often underreported. In the case of radiopharmaceuticals, this monitoring is more complex due to the possibility of delayed reactions and underreporting. A scoping review was conducted of questionnaires that assess knowledge, attitudes, and practices of pharmacovigilance among healthcare professionals, and the Delphi method was applied to develop a questionnaire in portuguese for this evaluation. The scoping study resulted in 14 studies that served as the Foundation for the development of a new questionnaire, which aims to assess healthcare professionals’ understanding and practices related to radiopharmaceutical pharmacovigilance. The developed questionnaire contains 42 questions, divided into four sections: Sociodemographic Data, Knowledge about Pharmacovigilance, Attitudes and Practices Regarding Reporting Adversa Reactions to Radiopharmaceuticals, and Motivations and Barriers to Regarding Adversa Reactions to Radiopharmaceuticals. A validated questionnaire developed through a Delphi study emphasized the need for acessible reporting systems and ongoing education for professionals. Establishing na eficiente reporting culture is crucial for ensuring patient safety and optimizing the clinical use of radiopharmaceuticals.

Keywords

Pharmacovigilance Helthcare professoals´ Radiopharmaceutical Spontaneous reports Nuclear medicine questionnaire Adverse drug reactions Portugal Adverse reation notification