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Advisor(s)
Abstract(s)
Introduction: Acetyl-L-Carnitine (ALC), a natural occurring compound in all mammalian
species, plays a variety of vital functions in the body. The most important are related to
mitochondria, namely the transport of fatty acids for energy production through β oxidation
and the control of acyl-CoA/CoA ratio. Due to this close interaction with cell bioenergetics, it
plays a role in many diseases, especially those related to the mitochondria. We propose to
characterize the action of ALC in mitochondrial bioenergetics and functional integrity.