Browsing by Issue Date, starting with "2012-10-27"
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- 99mTc-MAA for Lung Perfusion Scintigraphy: Impact of Counting Method on the Effective Number of Particles Administered and Particle Aggregation Over TimePublication . Costa, Pedro; Cunha, Lídia; Soares, Sofia; Mendes, Ângela; Queiroz, Ana; Nunes, Amélia; Ferreira, Elisabete; Botelho, Elisa; Sousa, Maria C.; Castro, Rosa; Pires, Laucena; João, M. Faria; Metello, Luís F.: 99mTc-MAA (macroaggregates of albumin) is the selected radiopharmaceutical for the Lung Perfusion Scintigraphy. It is retained in lung capillaries by mechanical blockage resulting in local microembolization. Care should be taken concerning not only particle size but also the number of particles administered to patients, particularly those who present with special conditions (pulmonary hypertension, shunt or lung transplant). European Pharmacopoeia only requires the assessment of particle size. This work aims to characterize particle size and particle aggregation of two commercial brands of MAA kits and to compare particle counting methods
- 99mTc-MAA for Lung Perfusion Scintigraphy: Impact of Counting Method on the Effective Number of Particles Administered and Particle Aggregation Over TimePublication . Costa, Pedro; Cunha, Lídia; Soares, Sofia; Mendes, Ângela; Queiroz, A. Isabel; Nunes, Amélia; Ferreira, Elisabete; Botelho, Elisa; Sousa, Conceição; Castro, Rosa; Pires, Laucena; João, M. Faria; Metello, Luís F.Introduction: 99mTc-MAA (macroaggregates of albumin) is the selected radiopharmaceutical for the Lung Perfusion Scintigraphy. It is retained in lung capillaries by mechanical blockage resulting in local microembolization. Care should be taken concerning not only particle size butalso the number of particles administered to patients, particularly those who present with special conditions (pulmonary hypertension, shunt or lung transplant). European Pharmacopoeia only requires the assessment of particle size. This work aims to characterize particle size and particle aggregation of two commercial brands of MAA kits and to compare particle counting methods.
- Nuclear Medicine Technologists Basic and Advanced Practice: What Does it Really Means?Publication . Metello, Luís F.; Costa, Pedro; Lemos, Joana; Ferreira, Sara; Vieira, Domingos; Fonseca, Abigaíl; Soares, Sofia; Cunha, LídiaNuclear Medicine is an independent medical specialty for almost fifty years. If that is quite clear and widely accepted, being in the basis and the justification for specialization between the distinct professionals involved, in many countries there is one exception: the Technologists. Since, in some countries, Nuclear Medicine is part of Medical Imaging area (which could include different specialties such as Radiology or Ultrasonography and, in a more restrict number of countries, even Radiotherapy), the “versatility” of Technologists might be somehow appreciated by some of the parts involved. Nevertheless, there are critical issues that need to be addressed - like the ability and capacity to perform distinct Practices at a certain level of autonomy and responsibility - and the final positions might be very distinct from one to another country.
- Acetyl-L-Carnitine Improves Cell BioenergeticsPublication . Cunha, Lídia; Bravo, Joana; Costa, Pedro; Fernandes, Sílvia; Oliveira, Marta; Castro, Rosa; Metello, Luís F.; Summavielle, TeresaIntroduction: Acetyl-L-Carnitine (ALC), a natural occurring compound in all mammalian species, plays a variety of vital functions in the body. The most important are related to mitochondria, namely the transport of fatty acids for energy production through β oxidation and the control of acyl-CoA/CoA ratio. Due to this close interaction with cell bioenergetics, it plays a role in many diseases, especially those related to the mitochondria. We propose to characterize the action of ALC in mitochondrial bioenergetics and functional integrity.