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Dual-action peptides as potential novel topical agents for treatment of skin and soft tissue infections

2018-05-18Conference object Open access
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dc.contributor.authorGomes, Ana
dc.contributor.authorBessa, Lucinda
dc.contributor.authorFerraz, Ricardo
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorGameiro, Paula
dc.contributor.authorTeixeira, Cátia
dc.contributor.authorGomes, Paula
dc.date.accessioned2024-06-17T14:31:11Z
dc.date.available2024-06-17T14:31:11Z
dc.date.issued2018-05-18
dc.description.abstractChronic skin and soft-tissue infections (SSTI) such as diabetic foot ulcers (DFU) exhibit signs and symptoms that are consistent with localized bacterial biofilms that contribute to tissue destruction, delayed woundhealing and other serious complications. As such, most current approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagenbased) to boost reestablishment of the skin tissue. While efficient production of recombinant human collagen remains an unmet goal, an alternative sensible option may be the design of formulations containing collagen-boosting instead of collagen-like components. Actually, collagen-boosting peptides, e.g., Matrikines®, are already used in cosmetics to promote extracellular matrix production, rebuilding structure and restoring all functions of healthy skin. Additionally, many antimicrobial peptides (AMP) can also act as wound-healing peptides, thus displaying the dual antimicrobial and tissue-regenerating properties highly desired in novel topical agents for treatment of SSTI. With the increasing prevalence of multi-drug resistant bacteria, and considering the burden that DFU alone represents to human health and healthcare facilities, the development of novel topical agents for effective treatment for this and other severe SSTI is an urgent need.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGomes, A., Bessa, L., Ferraz, R., Prudêncio, C., Gameiro, P., Teixeira, C., & Gomes, P. (2018). Dual-action peptides as potential novel topical agents for treatment of skin and soft tissue infections. Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology, 45. https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdfpt_PT
dc.identifier.isbn978-989-20-8533-3
dc.identifier.urihttp://hdl.handle.net/10400.22/25678
dc.language.isoengpt_PT
dc.publisherEscola Superior de Saúde P.Portopt_PT
dc.relationFundação para a Ciência e Tecnologia (FCT), Portugal, for funding LAQV-REQUIMTE through project UID/QUI/50006/2013 and for doctoral grant PD/BD/135073/2017 (AG). Thanks are also due to “CCDR-N/NORTE2020/Portugal 2020” for funding through project DESignBIOtechHealth (ref. Norte-01-0145-FEDER-000024)pt_PT
dc.relation.publisherversionhttps://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdfpt_PT
dc.subjectChronic skinpt_PT
dc.subjectSSTIpt_PT
dc.titleDual-action peptides as potential novel topical agents for treatment of skin and soft tissue infectionspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
oaire.citation.startPage45pt_PT
oaire.citation.titleBook of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnologypt_PT
person.familyNameFerraz
person.familyNamePrudêncio
person.givenNameRicardo
person.givenNameCristina
person.identifier1200571
person.identifier.ciencia-id001E-71CE-F92D
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.orcid0000-0002-1761-117X
person.identifier.orcid0000-0002-9920-936X
person.identifier.ridG-5639-2011
person.identifier.scopus-author-id24464208500
person.identifier.scopus-author-id6508057930
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationa5a8faa7-12a5-4b1c-bced-44c895677397
relation.isAuthorOfPublication881a8ad5-ab13-4e49-89f4-08ca61cc81e3
relation.isAuthorOfPublication.latestForDiscoverya5a8faa7-12a5-4b1c-bced-44c895677397

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