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Orientador(es)
Resumo(s)
Chronic skin and soft-tissue infections (SSTI) such as diabetic foot ulcers (DFU) exhibit signs and symptoms that are consistent with localized bacterial biofilms that contribute to tissue destruction, delayed woundhealing and other serious complications. As such, most current approaches for advanced wound care aim at providing antimicrobial protection to the open wound together with a matrix scaffold (often collagenbased) to boost reestablishment of the skin tissue. While efficient production of recombinant human collagen remains an unmet goal, an alternative sensible option may be the design of formulations containing collagen-boosting instead of collagen-like components. Actually, collagen-boosting peptides, e.g., Matrikines®, are already used in cosmetics to promote extracellular matrix production, rebuilding structure and restoring all functions of healthy skin. Additionally, many antimicrobial peptides (AMP) can also act as wound-healing peptides, thus displaying the dual antimicrobial and tissue-regenerating properties highly desired in novel topical agents for treatment of SSTI. With the increasing prevalence of multi-drug resistant bacteria, and considering the burden that DFU alone represents to human health and healthcare facilities, the development of novel topical agents for effective treatment for this and other severe SSTI is an urgent need.
Descrição
Palavras-chave
Chronic skin SSTI
Contexto Educativo
Citação
Gomes, A., Bessa, L., Ferraz, R., Prudêncio, C., Gameiro, P., Teixeira, C., & Gomes, P. (2018). Dual-action peptides as potential novel topical agents for treatment of skin and soft tissue infections. Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal Biotechnology, 45. https://paginas.ess.ipp.pt/ebtm/2018/3EBtM_BookOfAbstracts.pdf
Editora
Escola Superior de Saúde P.Porto