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In vitro antimicrobial activity of volatile compounds from the Lichen Pseudevernia furfuracea (L.) Zopf. against multidrug-resistant bacteria and fish pathogens

2024-11-15Journal article Open access
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dc.contributor.authorEssadki, Yasser
dc.contributor.authorHilmi, Adel
dc.contributor.authorCascajosa-Lira, Antonio
dc.contributor.authorGirão, Mariana
dc.contributor.authorDarrag, El Mehdi
dc.contributor.authorRosário Martins, Maria
dc.contributor.authorRomane, Abderrahmane
dc.contributor.authorZerrifi, Soukaina El Amrani
dc.contributor.authorMugani, Richard
dc.contributor.authorTazart, Zakaria
dc.contributor.authorRedouane, El Mahdi
dc.contributor.authorJos, Angeles
dc.contributor.authorCameán, Ana M.
dc.contributor.authorVasconcelos, Vitor
dc.contributor.authorCampos, Alexandre
dc.contributor.authorKhalloufi, Fatima El
dc.contributor.authorOudra, Brahim
dc.contributor.authorBarakate, Mustapha
dc.contributor.authorCarvalho, Maria de Fátima
dc.date.accessioned2024-11-19T10:41:01Z
dc.date.available2024-11-19T10:41:01Z
dc.date.issued2024-11-15
dc.description.abstractLichens are symbiotic organisms with unique secondary metabolism. Various metabolites from lichens have shown antimicrobial activity. Nevertheless, very few studies have investigated the antimicrobial potential of the volatile compounds they produce. This study investigates the chemical composition and antimicrobial properties of volatile compounds from Pseudevernia furfuracea collected in two regions of Morocco. Hydrodistillation was used to obtain volatile compounds from samples collected in the High Atlas and Middle Atlas. Gas chromatography–mass spectrometry (GC-MS) analysis identified phenolic cyclic compounds as the primary constituents, with atraric acid and chloroatranol being the most abundant. Additionally, eight compounds were detected in lichens for the first time. The antimicrobial activity of these compounds was assessed using disc diffusion and broth microdilution methods. Both samples demonstrated significant antimicrobial effects against multidrug-resistant human bacteria, reference microorganisms, fish pathogens, and Candida albicans, with minimum inhibitory concentrations (MICs) ranging from 1000 µg/mL to 31.25 µg/mL. This study provides the first report on the volatile compounds from Pseudevernia furfuracea and their antimicrobial effects, particularly against fish pathogens, suggesting their potential as novel antimicrobial agents for human and veterinary use. Further research is warranted to explore these findings in more detail.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEssadki, Y., Hilmi, A., Cascajosa-Lira, A., Girão, M., Darrag, E. M., Martins, R., Romane, A., El Amrani Zerrifi, S., Mugani, R., Tazart, Z., Redouane, E. M., Jos, A., Cameán, A. M., Vasconcelos, V., Campos, A., El Khalloufi, F., Oudra, B., Barakate, M., & Carvalho, M. de F. (2024). In vitro antimicrobial activity of volatile compounds from the Lichen Pseudevernia furfuracea (L.) Zopf. Against multidrug-resistant bacteria and fish pathogens. Microorganisms, 12(11), Artigo 11. https://doi.org/10.3390/microorganisms12112336pt_PT
dc.identifier.doi10.3390/microorganisms12112336pt_PT
dc.identifier.eissn2076-2607
dc.identifier.urihttp://hdl.handle.net/10400.22/26419
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationThe authors would like to acknowledge the TOXICROP project (H2020-823860). Antonio Cascajosa-Lira would like to acknowledge the Spanish Ministerio de Universidades (FPU 2019-01247). MFC wishes to acknowledge the CEEC program supported by FCT (CEECIND/02968/2017), Fundo Social Europeu and Programa Operacional Potencial Humano. The authors also acknowledge Strategic Funding UIDB/04423/2020, through national funds provided by FCT and the European Regional Development Fund (ERDF) and Fundo Social Europeu, and the Project PID2023-147444OB-I00 (funded by the MICIU/AEI).pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-2607/12/11/2336pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectLichenspt_PT
dc.subjectPseudevernia furfuraceapt_PT
dc.subjectVolatile compoundspt_PT
dc.subjectMultidrug-resistant bacteriapt_PT
dc.subjectFish pathogenspt_PT
dc.subjectMinimum inhibitory concentrationpt_PT
dc.titleIn vitro antimicrobial activity of volatile compounds from the Lichen Pseudevernia furfuracea (L.) Zopf. against multidrug-resistant bacteria and fish pathogenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume12(11)pt_PT
person.familyNameMartins
person.givenNameRosario
person.identifier.ciencia-idA919-DB40-EF10
person.identifier.orcid0000-0002-9882-4651
person.identifier.scopus-author-id21834368700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication82a7c349-c88e-450f-adc7-3331d69149cf
relation.isAuthorOfPublication.latestForDiscovery82a7c349-c88e-450f-adc7-3331d69149cf

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