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- New therapeutic approaches based on ionic liquidsPublication . Ferraz, Ricardo; Teixeira, Cátia; Prudêncio, Cristina; Teixeira, Dulce; Vieira, Mónica; Gomes, PaulaIonic liquids (ILs) are currently defined as salts (with at least one organic ion) stable above their melting point. They began to be used mainly as solvents, but quickly drew the attention of the Life Sciences, as some of the characteristics of those compounds may be relevant in therapeutic applications. ILs can show more interesting physicochemical properties at the level of active pharmaceutical ingredients such as water solubility, in addition to the fact that ILs (liquids at room temperature and/or human body temperature) do not present polymorphism, an aspect which often limits the conditions of use and therapeutic efficacy of solid active pharmaceutical ingredients. This line of research seeks, through a careful choice of the ions, to fine-tune some of these properties, and to study the combination of two bioactive molecules that have ionizable groups of opposite charge, forming ionic liquids with a dual therapeutic effect.
- Book of abstracts 4th Meeting on Medicinal Biotechnology (4EBtM)Publication . Costa, Ana Rita; Dias, Ana Rita; Prudêncio, Cristina; Borges, Cristina; Teixeira, Dulce; Almeida, Joana; Vieira, Mónica; Coelho, Pedro; Ferraz, Ricardo; Cunha, SofiaThese meetings have been held once a year since 2015 and have played an important role as a point of contact among several professionals and students in Medicinal Biotechnology. Like the Medicinal Biotechnology field itself, these meetings have also been expanding, not only in the number of participants, but also in their geographical origin. Therefore, it is our goal to act as an interface between students and biotechnology companies/researchers, as well as to increasingly promote networking, projects and collaborations within this field for the upcoming years.
- Desenvolvimento, avaliação e quantificação de biomoléculasPublication . Teixeira, Dulce; Ferraz, Ricardo; Prudêncio, Cristina; Vieira, MónicaThe synthesis of new biomolecules, the evaluation of their potential biological activity or therapeutic application, as well as the monitoring of intervening biomolecules in pathological contexts is of great interest to the scientific, medical and pharmaceutical community. In the validation of synthesis, extraction and biological interaction methods, chromatographic methods play a fundamental role in the identification and quantification of these biomolecules of interest, whether these are potential new drugs, biomarkers or environmental indicators. In order to contribute to the identification and quantification of biomolecules with potential (bio) technological application, new chromatographic methodologies have been developed, namely based on liquid chromatography, using HPLC-DAD. In the development of new biomolecules, the bioactivity of compounds with potential application has been studied, such as Quinoxaline derivatives. In addition to the antimicrobiological action, the effect of this family of compounds in the modeling of oxidative stress in pathological context has been evaluated.
- Biotechnology and biochemistry laboratorial education through the SARS-CoV2 pandemic: challenges, truths and takeawaysPublication . Almeida, Joana; Pereira, Cassilda; Coelho, Pedro; Teixeira, Dulce; Louçano, Marta; Bento, C.; Cerqueira, Maria João; Prudêncio, Cristina; Ferraz, Ricardo; Vieira, MónicaIn early 2020, the COVID-19 pandemic forced the higher education institutions to adapt to a new form of teaching and learning, from presential to full remote, blended and hybrid environment.
- Book of abstracts of the III Encontro de Biotecnologia Medicinal/ I Iberian Congress on Medicinal BiotechnologyPublication . Costa, Ana Rita; Prudêncio, Cristina; Teixeira, Dulce; Almeida, Joana; Vieira, Mónica; Coelho, Pedro; Ferraz, Ricardo; Cunha, Sofia; Dias, Ana RitaEstes encontros de Biotecnologia Medicinal iniciaram-se em 2015 e sentimos que estamos a crescer, tal como a Biotecnologia Medicinal. Esta área da Biotecnologia tem ganho relevância, quer em empresas, quer a nível académico, criando interfaces entre a biologia molecular, a microbiologia e a química medicinal.
- Book of Abstracts of 5th Meeting of Medicinal Biotechnology (5MBtM) and 2nd Iberian Congress on Medicinal BiotechnologyPublication . Sieiro, Carmen; Pereira, Cassilda; Prudêncio, Cristina; Oliveira, Daniela; Teixeira, Dulce; Barros, Eduarda; Almeida, Joana; Cerqueira, Maria João; Louçano, Marta; Vieira, Mónica; Coelho, Pedro; Ferraz, Ricardo