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- Evaluation of quinoxaline-1,4-dioxide and derivatives biological activity in normal and tumour cellPublication . Silva, Liliana; Coelho, Pedro; Soares, Raquel; Prudêncio, Cristina; Vieira, MónicaQuinoxaline derivatives are synthetic heterocyclic compounds with multiples pharmacological applications and biological effects. Previous studies of our group about the biological activity in eukaryotic and prokaryotic microbial models with quinoxaline-1,4-dioxide (QNX) derivatives concluded a selective antimicrobial activity in gram negative strains. To further evaluate these compounds’ potential, we investigated the biologic activity in vitro of this chemical structures in normal and tumour cells lines.