ESS - DM - Mestrado Europeu em Tecnologia Médica e Negócios em Saúde
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- From bench to market: Optimizing a cartilage-on-chip platform for Osteoarthritis research and analyzing the current and future landscape of Organ-on-Chip TechnologiesPublication . Hernández-Montoya, Ariadna; Ribeiro, Maria Cristina de Castro; Cillero-Pastor, BertaOrgan-on-Chip (OoC) systems are microfluidic medical devices engineered to replicate the physiological functions and microenvironment of human organs and tissues in vitro. These systems are designed to overcome the limitations of current in vitro models by providing an accurate platform for drug discovery and disease modeling. Osteoarthritis (OA) is a joint disease characterized by cartilage degeneration, where traditional models fail to replicate its biomechanical and biochemical characteristics. In this study, a Cartilage-on-Chip (CoC) device with hMSCs was used to mimic the disease microenvironment. Market research including a survey direct to OoC stakeholders, was performed to understand the current and future trends of Organ-on-Chip. The CoC was successfully optimized to be used with hMSCs and Geltrex, improving is usability and utility, a set of recommendations were developed to improve the performance of the CoC, and help future users to be efficient with OoC. After the analysis of the market research, it was noted that funding in the field is growing, and according to the opinion of the survey participants, the use of these systems promises to improve biomedical research on fields such as neurology and immunology, and advances are expected from training, scalability and standardization to integrated biosensors and multi-organ models.