Browsing by Author "Silva, M."
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- Antimicrobial activity of pyrazine and quinoxaline N,N’-dioxide heterocyclic compoundsPublication . Vieira, Mónica; Ferraz, Ricardo; Fernandes, Rúben; Noronha, João Paulo; Silva, M.; Prudêncio, CristinaThe nitrogen heterocyclic organic compounds 1,4 dioxide pyrazine and quinoxaline derivatives have been widely studied due to their potential use as synthetic drugs. The thermochemical study of three N,N´-dioxides: 2,3,5-trimethylpyrazine-1,4-dioxide, tetramethylpyrazine-1,4-dioxide and 6-chloro-2,3-dimethilquinoxaline 1,4-dioxide has been recently developed in order to establish relationships among the energetical, structural and reactivity properties [4,5]. Several studies have reported their pharmacological activity, particularly as antimicrobial agents [1,2,3]. It has also been established a relation between energetical and structural properties and biological activity, once these compounds present N – oxide bonds, increasing their oxidative capacity. The present work reports the study of antimicrobial activity for those compounds against the bacteria Geobacillus stearothermophylus, Staphylococcus aureus, Streptococcus agalactiae, Escherichia coli and also against the yeasts Saccharomyces cerevisiae PYCC 4072, Candida albicans PYCC3436T, Candida tropicalis PYCC, Issatchenka Orientalis PYCC. The determination of the minimal inhibitory concentration (MIC), points to an antimicrobial activity and the preliminary results indicate that these compounds may be potential candidates as antimicrobial drugs with clinical, agriculture or food industries applications.
- Antimicrobial activity of quinoxaline 1,4-dioxide and three derivativesPublication . Vieira, Mónica; Fernandes, Rúben; Noronha, João Paulo; Silva, M.; Prudêncio, CristinaO presente trabalho descreve o estudo da actividad e antimicrobiana de quarto derivados da quinoxalina N,N-dióxido: quinoxalina 1,4-dióxido, 2-metilquinoxalina 1,4- dióxido, 6-cloro-2,3-dimetilquinoxalina 1,4-dióxido e 3-benzoil-2-metilquinoxalina 1,4- dióxido contra as estirpes bacterianas Geobacillus stearothermophilus ATCC 10149, Escherichia coli ATCC 25922, Escherichia coli HB101, Escherichia coli (blaTEM, blaCTX-M) e Salmonella (blaCTX-M), assim como contra a estirpe de levedura Saccharomyces cerevisiae PYCC 4072. A determinação da concentração mínima inibitória (MIC) foi realizada pelo método de diluição. Os valores de MIC’s foram estimados para cada composto e estirpe. Os resultados obtidos sugerem potenciais novas drogas para quimioterapia.
- Exposure of Mytilus galloprovencialis to diarrhetic shellfish poisoning toxin: food safety implicationsPublication . Silva, M.; Campos, A.; Pérez, D.; Azevedo, C.; Costa, P. Reis; Martins, J. C.; Vasconcelos, V.; Freitas, MarisaThroughout the world, toxins produced by algae are responsible for approximately 60000 human food poisonings yearly. Shellfish toxins cause damage to wildlife and have a negative economic impact on recreation, tourism and shellfish industry, being almost a worldwide phenomenon. Dinoflagelates such as Dynophysis and Prorocentrum lima are considered a primary producer of diarhetic shellfish toxins, such as Okadaic Acid (OA) and Dinophysistoxins (DTXs), which can be accumulated in the tissues of the bivalves. Bioaccumulation process could increase the concentration of OA and DTXs at risky level, making bivalves unsafe for human consumption.
- Health care staff perception of noise in neonatal intensive care units: a questionnaire survey from NeoNoise ProjectPublication . Alberto Alves Carvalhais, Carlos; Santos, J.; Coelho, M.; Xavier, A.; Silva, M.A hospital Neonatal Intensive Care Unit (NICU) is designed to treat premature infants who need special care. These kind of units have become quite sophisticated, with a sort of medical devices that support an array of health care staff, such, physicians, nurses, health technicians, etc. (Konkani & Oakley, 2012). Noise in NICU is recognized as an agent with negative implications on health and well-being of premature infants (Nicolau, Casal, Lopes, & Kronenberg, 2005) and health professionals (Carvalhais, Santos, Vieira da Silva, & Xavier, 2015). Noise in NICU, and its effects on patients and staff, such as physiological and psychological disorders, has become an important issue, particularly because in these case patients are mainly premature infants. Noise as a stressor does not only put pressure on the workers and may result in a higher error occurrence, but also affect in a negative way, the healing process of patients (Siegmann & Notbohm, 2013). Figure 1, presents a general noise reaction scheme which can be used for hypothesis testing in noise epidemiology considering the cause-effect (Babisch, 2002).
- P-1186 - The recovery process of persons living with psychiatric disabilities: values and principles of nova aurora community association psychosocial rehabilitation programPublication . Marques, António; Morais, A.; Campos, Filipa; Silva, M.; Silva, L.; Almeida, R.The Nova Aurora Community Association psychosocial rehabilitation program was developed based in the most current values of Psychosocial Rehabilitation. Some nuclear assumptions were considered, such as a) suppressing the disease stigma, b) defocusing from the mental ill role, promoting empowerment and self-determination, c) developing personal competencies directly related to the individuals’ social integration specific context (readiness, cognitive, social, emotional stress management, employability).