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- Morphofunctional characterization of the ileum in a type 1 diabetes rat model 7Publication . Henriques, Vanessa Mendes; Monteiro, Salomé Gonçalves; Vieira, Filipa Quintela; Sá, Paulo Correia de; Araújo, Margarida DuarteDiabetes mellitus (DM) is a metabolic disorder that affects 1 in 12 people with high mortality and morbidity. Knowing that about 76% of diabetic patients have gastrointestinal complications, we decided to characterize morphologically and functionally the ileum of a rat (Rattus norvegicus, Wistar) model that mimics type 1 DM. Diabetes was chemically induced by a single intraperitoneal injection of streptozotocin (STZ, 55mg/kg). All animals were used 14 days after injection with saline (CTRL-group) or STZ (STZ-group).