ESS - ACSP - Análises Clínicas e Saúde Pública
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- Peripheral metabolism in rat with olanzapine subchronic treatment supplemented with acetyl-L carnitinePublication . Amorim, Manuela; Silva, Ana Isabel; Alves, Cecília Juliana; Monteiro, Pedro R.; Magalhães, Ana; Summavielle, TeresaOlanzapine (Olz) have been reported to promote higher risk for metabolic side-effects, such as obesity, dyslipidemia, and diabetes. Moreover/On the other hand, acetyl-L-carnitine (ALC) has been reported to improve homeostasis. This study aims to explore if ALC could improve metabolic homeostasis due to Olz effects on a rodent model. We investigated the effects of subchronic administration of Olz and with the addition of ALC on body weight gain and glucose metabolism in Wistar rats. Mid-term Olz exposure in rats significantly increases blood glucose levels in fasting and after the overload of glucose compared to the sali-ne-treated group (p<0.05). However, in rats mid-term treated with olanzapine plus acetyl-L-carnitine had no significant differences in fasting blood glucose levels compared to the saline-treated group. The findings suggest that ALC added to Olz treatment appeared to be effective to improve glucose metabolism during olanzapine subchronic treatment.