ESS - MN - Medicina Nuclear
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Browsing ESS - MN - Medicina Nuclear by Author "Alves, F."
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- Developing advanced biological models to study effects of low doses of ionizing radiation: our experience.Publication . Lemos, Joana; Costa, Pedro; Cunha, Lídia; Carvalho, António P.; Vasconcelos, Vítor; Silva, Regina; Fernandes, Sílvia; Santos, João; Cunha, Micaela; Crespo, Paulo; Metello, Luís F.; Alves, F.The biological effects of high doses of ionizing radiation are reasonably well studied and documented. Nevertheless, there is a clear lack of evidence concerning biological effects of Low Doses, namely at medical imaging levels, as those characterizing Nuclear Medicine and Radiology typical environments. Recognizing limitations and translational difficulties of the actual monolayer cellular models, our group has produced efforts to develop advanced biological models, namely using three-dimensional cell cultures and a less explored animal model (Zebrafish - which allow access to inter-generational data, while characterized by a great genetic homology). This work aims to exhibit preliminary results already obtained
- Direct production of 99mTc-Technetium using low energy cyclotrons and radionuclidic purity: our results so far using natMo-MolybdenumPublication . Metelo, Luís Francisco; Costa, Pedro; Cunha, L.; Jonhson, R.; Matei, L.; Gelbart, W.; Obermair, J.; Artner, C.; Lass, P.; Currie, G.; Craciun, L.; Niculae, D.; Carmo, S.; Alves, F.; Botello, M.Despite the global crisis concerning 99mTc delivering to Nuclear Medicine Departments there isn’t yet a reliable solution. The cyclotron direct production of 99mTc, using the 100Mo(p,2n)99mTc nuclear reaction is our attempt to approach the problem, aiming to become efficient, reliable and sustainable from points of view as reducing drastically the radioactive waste being produced and becoming beneficial for all the involved parts. Between several critical factors, radionuclidic purity of cyclotron-produced 99mTc is being pointed as an issue of concern.
- PET aplicada à Medicina Moderna: prova de conceito baseada na produção de Titânio-45 ( 45Ti)Publication . Costa, Pedro; Alves, F.; Naia, M. DuarteOs paradigmas modernos da Medicina baseada em Evidência e/ou Ciência, bem como os conceitos relacionados com a Medicina Personalizada, têm levado ao crescente uso de meios complementares de diagnóstico, cada vez mais sensíveis específicos. Nesse contexto, as metodologias de imagem médica têm especial relevo .Dentro destas, vários exemplos podem ser destacados, mas a Medicina Nuclear, baseada no uso de radiofármacos, é especialmente importante ao nível do estudo funcional e molecular dos mais diversos processos patológicos.
- PET imaging using titanium-45: Could it be useful?Publication . Costa, Pedro; Metello, Luís; Alves, F.; Naia, M. DuarteIn the last decade a wider application of positron emission tomography (PET) as one of the most powerful medical imaging technologies was observed. This was largely due to the increased availability of equipment dedicated to production of radioisotopes, mainly due to the installation of low energy cyclotrons in hospitals, research institutes and pharmaceutical industries specialized in radiopharmaceutical production.
- Using low energy medical cyclotrons to produce 99mTc - TechnetiumPublication . Metello, L. F.; Gelbart, W.; Cunha, L.; Carmo, S.; Artner, C.; Alves, F.This paper refers to work in progress, addressing the global trouble in delivering 99mTc to Nuclear Medicine Departments, Aiming to develop an efficient, safe and economical way to directly produce Technetium 99metastable (99mTc) using lowenergy - so-called “medical” - cyclotrons. The present delivery strategy has intrinsic limitations because it is not only based on old nuclear reactors, but also limits the weekly agenda workflow. Our approach is distinct, and is based on the broad distribution network of the low energy cyclotrons and the accessibility of Molybdenum 100 (100Mo) as the target material, so the system here presented, is not based on the use of Nuclear Reactors and highly enriched (or even low enriched) Uranium 235 (235U), but entirely complying with the current international trends and directives, concerning the need to reduce the use of this potential highly critical target material. The direct production technique is based on the nuclear reaction 100Mo(p,2n)99mTc whose production yields have already been widely documented. The 99mTc is produced in a routine, reliable and efficient manner that, remaining always flexible, entirely blends with established protocols.