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Browsing by Issue Date, starting with "2012-11-20"

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  • Developing advanced biological models to study effects of low doses of ionizing radiation: our experience.
    Publication . Lemos, Joana; Costa, Pedro; Cunha, Lídia; Carvalho, António P.; Vasconcelos, Vítor; Silva, Regina; Fernandes, Sílvia; Santos, João; Cunha, Micaela; Crespo, Paulo; Metello, Luís F.; Alves, F.
    The biological effects of high doses of ionizing radiation are reasonably well studied and documented. Nevertheless, there is a clear lack of evidence concerning biological effects of Low Doses, namely at medical imaging levels, as those characterizing Nuclear Medicine and Radiology typical environments. Recognizing limitations and translational difficulties of the actual monolayer cellular models, our group has produced efforts to develop advanced biological models, namely using three-dimensional cell cultures and a less explored animal model (Zebrafish - which allow access to inter-generational data, while characterized by a great genetic homology). This work aims to exhibit preliminary results already obtained
    2012-11-20Conference object Open access Show more
  • Should new Nuclear Reactors be considered as an option to solve Technetium shortage problem?
    Publication . Metello, Luís F.; Cunha, Lídia; Costa, Pedro; Vieira, Domingos; Alves, Francisco; Botelho, Maria Filomena; Gelbart, W.; Artner, Christoph; Nader, Michael; Schibli, Roger; Jensen, Mikael
    Worldwide, more than 80% of Nuclear Medicine procedures use a radiotracer produced through a 99Mo/99mTc generator - 99mTc – Technetium 99metastable. Most of the radiochemistry and equipments is optimized for this radioisotope characteristics already for more than 35 years, making it very difficult to replace. Worldwide production of 99Mo is based essentially with only five Nuclear Reactors that are becoming obsolete and fragile with aging, shutting down more and more frequently as they approach the end of their shelf-life. Seeking for solutions, some Governments – and the EU – plan to build new dedicated Nuclear Reactor(s). Our work defends another option.
    2012-11-20Conference object Open access Show more