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Orientador(es)
Resumo(s)
Stem cells, characterised by their remarkable re-generative potential and ability to differentiate into different cell types, hold immense promise in thera-peutic applications. The umbilical cord is one source of stem cells which is easy, safe, and non-invasive for the mother and infant. BebéVida, a cryopreservation laboratory in Porto, served as the pivotal setting for this study. Beyond the therapeutic potential of stem cells, this study focuses on the intricate relationship between blood groups and the immune system. Vari-ations in immune cell numbers across different blood groups suggest a potential influence of ABO antigens on early immune cell composition. The human immune system undergoes a remarkable journey from embry-onic stages to infancy, marked by a gradual transition from reliance on innate immunity, which is genetically encoded, to the development of adaptive responses. ABO blood group antigens, determined by genetic in-heritance, further shape immune characteristics, with antibodies passed from the mother providing tempo-rary protection until the infant’s immune system ma-tures. This intricate interplay between genetic factors, maternal influence, and blood group genetics lays the foundation for lifelong immune health and disease susceptibility. As it has been demonstrated in differ-ent studies, there are potential links between ABO blood groups and cancer, cardiovascular, infectious (bacteria, viruses, and parasites), metabolic, and aller-gic diseases, and that is why this study was conducted, to understand the influence of blood groups on the umbilical cord blood immune cell profile. The parame-ters analysed were the nucleated cells, WBC, neutro-phils, monocytes, lymphocytes, NRBC, and platelets. In fact, this study underscores the dual significance of umbilical cord stem cells in therapeutics and the intri-cate interplay between blood groups and immune sys-tem dynamics. By elucidating these relationships, we can advance personalized medicine approaches and improve our understanding of disease predisposition across diverse population.
Descrição
Palavras-chave
Umbilical cord blood Abo blood group Transfusion medicine
Contexto Educativo
Citação
Pina, J., Oliveira, M., Ferraz, R., & Gomes, A. (2026). Blood group influence in umbilical cord blood immune cell profile. Book of Abstracts of the 8th Meeting on Medicinal Biotechnology, 57. https://edicoes.ipp.pt/index.php/books/catalog/book/251
Editora
Politema