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Integration of microfluidics and nanoezyme peroxidase for colorimetric detection of neurotransmitters

2024Conference object Open access
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dc.contributor.authorSousa, Cristina
dc.contributor.authorChiussi, Stefano
dc.contributor.authorMoreira, Felismina T.C.
dc.date.accessioned2024-11-08T15:39:04Z
dc.date.available2024-11-08T15:39:04Z
dc.date.issued2024
dc.descriptionThis study was financed by project IBEROS+ (0072_IBEROS_MAIS_1_E, Interreg-POCTEP 2021-2027).pt_PT
dc.description.abstractThe integration of Microfluidics and Nanozyme peroxidase for the Colorimetric detection of Neurotransmitters represents a cutting-edge approach in neurochemical analysis. Microfluidics allows precise manipulation of small fluid volumes, reducing reagent consumption and accelerating reactions while integrating multiple analytical steps on a single chip. Nanozyme peroxidases, mimicking natural peroxidases, provide enhanced stability and catalytic efficiency at a lower cost. The colorimetric detection mechanism signals the presence of neurotransmitters through a visible color change, making it sensitive and easy to interpret for real-time analysis. Detecting neurotransmitters like acetylcholine(ACH) is crucial for understanding and diagnosing various neurological conditions. Acetylcholine plays a key role in physiological processes such as muscle activation, memory function, and synaptic transmission. Abnormal levels are linked to disorders like Alzheimer's disease, myasthenia gravis, and Parkinson's disease. Accurate measurement aids in early diagnosis, monitoring disease progression, and evaluating treatment efficacy. A reliable detection method can advance our understanding of brain function and neurotransmitter dynamics. Real-time monitoring provides insights into how neurotransmitter fluctuations correlate with cognitive functions, behaviors, and responses to stimuli, essential for developing new therapeutic strategies and discovering novel drugs targeting neurotransmitter systems.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationSousa, C., Chiussi, S., & Moreira, F.T.C. (2024, Jun. 14). Integration of microfluidics and nanoezyme peroxidase for colorimetric detection of neurotransmitters [Poster presentation]. IBEROS+ - II Jornadas do Instituto de Biofabricação em Rede para o Envelhecimento Saudável, Porto, Portugalpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26370
dc.language.isoengpt_PT
dc.subjectNeurotransmitterspt_PT
dc.subjectNeurochemical analysispt_PT
dc.titleIntegration of microfluidics and nanoezyme peroxidase for colorimetric detection of neurotransmitterspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePorto, Portugalpt_PT
oaire.citation.titleIBEROS+ - II Jornadas do Instituto de Biofabricação em Rede para o Envelhecimento Saudávelpt_PT
person.familyNameChiussi
person.familyNameMoreira
person.givenNameStefano
person.givenNameFelismina
person.identifier970285
person.identifier1589429
person.identifier.ciencia-idC917-6A46-A270
person.identifier.orcid0000-0002-3933-8725
person.identifier.orcid0000-0003-4237-8952
person.identifier.ridD-6218-2014
person.identifier.scopus-author-id7004516152
person.identifier.scopus-author-id23486193000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicatione8f8c601-1b0f-4df4-b4b5-14be039a9b67
relation.isAuthorOfPublication9c13153d-a73a-49ff-b7f6-c9733bc6725e
relation.isAuthorOfPublication.latestForDiscovery9c13153d-a73a-49ff-b7f6-c9733bc6725e

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