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Functional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy: Cross-sectional Analyses of Baseline Data of the EUROCONDOR Project

2017Journal article Open access
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dc.contributor.authorB M Santos, Ana Rita
dc.contributor.authorRibeiro, Luísa
dc.contributor.authorBandello, Francesco
dc.contributor.authorLattanzio, Rosangela
dc.contributor.authorEgan, Catherine
dc.contributor.authorFrydkjaer-Olsen, Ulrik
dc.contributor.authorGarcía-Arumí, José
dc.contributor.authorGibson, Jonathan
dc.contributor.authorGrauslund, Jakob
dc.contributor.authorHarding, Simon P.
dc.contributor.authorLang, Gabriele E.
dc.contributor.authorMassin, Pascale
dc.contributor.authorMidena, Edoardo
dc.contributor.authorScanlon, Peter
dc.contributor.authorAldington, Stephen J.
dc.contributor.authorSimão, Sílvia
dc.contributor.authorSchwartz, Christian
dc.contributor.authorPonsati, Berta
dc.contributor.authorPorta, Massimo
dc.contributor.authorCosta, Miguel Ângelo
dc.contributor.authorHernández, Cristina
dc.contributor.authorCunha-Vaz, José
dc.contributor.authorSimó, Rafael
dc.date.accessioned2019-12-06T16:34:08Z
dc.date.available2019-12-06T16:34:08Z
dc.date.issued2017
dc.description.abstractThis cross-sectional study evaluated the relationship between 1) functional and structural measurements of neurodegeneration in the initial stages of diabetic retinopathy (DR) and 2) the presence of neurodegeneration and early microvascular impairment. We analyzed baseline data of 449 patients with type 2 diabetes enrolled in the European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR) study (NCT01726075). Functional studies by multifocal electroretinography (mfERG) evaluated neurodysfunction, and structural measurements using spectral domain optical coherence tomography (SD-OCT) evaluated neurodegeneration. The mfERG P1 amplitude was more sensitive than the P1 implicit time and was lower in patients with Early Treatment of Diabetic Retinopathy Study (ETDRS) level 20-35 than in patients with ETDRS level <20 (P = 0.005). In 58% of patients, mfERG abnormalities were present in the absence of visible retinopathy. Correspondence between SD-OCT thinning and mfERG abnormalities was shown in 67% of the eyes with ETDRS <20 and in 83% of the eyes with ETDRS level 20-35. Notably, 32% of patients with ETDRS 20-35 presented no abnormalities in mfERG or SD-OCT. We conclude that there is a link between mfERG and SD-OCT measurements that increases with the presence of microvascular impairment. However, a significant proportion of patients in our particular study population (ETDRS ≤35) had normal ganglion cell-inner plexiform layer thickness and normal mfERG findings. We raise the hypothesis that neurodegeneration may play a role in the pathogenesis of DR in many but not in all patients with type 2 diabetes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2337/db16-1453pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/15065
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://diabetes.diabetesjournals.org/content/66/9/2503pt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectDiabetes Mellitus, Type 2pt_PT
dc.subjectDiabetic Retinopathypt_PT
dc.subjectElectroretinographypt_PT
dc.subjectRetinal Degenerationpt_PT
dc.subjectRetinal Neuronspt_PT
dc.subjectRetinal Vesselspt_PT
dc.titleFunctional and Structural Findings of Neurodegeneration in Early Stages of Diabetic Retinopathy: Cross-sectional Analyses of Baseline Data of the EUROCONDOR Projectpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2510pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage2503pt_PT
oaire.citation.titleDiabetespt_PT
oaire.citation.volume66pt_PT
person.familyNameB M Santos
person.givenNameAna Rita
person.identifier.ciencia-id291A-15C5-9C96
person.identifier.orcid0000-0003-3761-3292
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationcf304315-48a2-4bae-a1d5-61a4c8e45274
relation.isAuthorOfPublication.latestForDiscoverycf304315-48a2-4bae-a1d5-61a4c8e45274

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