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Physical Exercise As Stabilizer For Alzheimer'S Disease Cognitive Decline: Current Status

2017Journal article Restricted access
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dc.contributor.authorMachado, Sergio
dc.contributor.authorFilho, Alberto Souza de Sá
dc.contributor.authorWilbert, Matheus
dc.contributor.authorBarbieri, Gabriela
dc.contributor.authorAlmeida, Victor
dc.contributor.authorGurgel, Alexandre
dc.contributor.authorRosa, Charles V.
dc.contributor.authorLins, Victor
dc.contributor.authorPaixão, Alexandre
dc.contributor.authorSantana, Kamila
dc.contributor.authorRamos, Gabriel
dc.contributor.authorNeto, Geraldo Maranhão
dc.contributor.authorPaes, Flávia
dc.contributor.authorRocha, Nuno
dc.contributor.authorMurillo-Rodriguez, Eric
dc.date.accessioned2019-07-15T16:59:51Z
dc.date.available2019-07-15T16:59:51Z
dc.date.issued2017
dc.description.abstractMental health decline is one of the main responsible factors for augments in health care costs, and diagnosis of Alzheimer’s disease (AD). Some studies stated physical exercise is useful for reduction in cognitive decline and AD. Moreover, a recent review argued that evidence are scarce due to few studies published and lack of configuration information of exercise protocol, such as intensity and duration of exercise, number of sessions and other relevant data, to allow appropriate assessment. Materials and Methods: Here, we discussed the possible confounders or factors responsible for these differences and possible neurophysiological mechanisms. Results: Most studies revealed a possible positive association between physical exercise and cognitive assessments. There are inconsistencies in studies design responsible for varying use of cognitive assessments and different assessments of fitness. However, these studies do not fail to provide evidence about the benefits of exercise, but fail to make it possible because of the lack of dose-response information in AD patients. Physical exercise of moderate intensity should be considered as standard recommendation to reduce cognitive decline, probably due to the improvement in neurodegenerative mechanisms, and the increase in neuroplastic and neuroprotective neurotrophic factors. Conclusion: Therefore, it is suggested that physical exercise is an important neuroprotective modulator, bringing significant control of the disease and amplifying brain functions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2174/1745017901713010181pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/14380
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712652/pt_PT
dc.subjectAlzheimer’s diseasept_PT
dc.subjectUnimodal and multimodal trainingpt_PT
dc.subjectCognitive functioningpt_PT
dc.subjectPhysical exercisept_PT
dc.titlePhysical Exercise As Stabilizer For Alzheimer'S Disease Cognitive Decline: Current Statuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage184pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage181pt_PT
oaire.citation.titleClinical Practice and Epidemiology in Mental Health :: Cp && Emhpt_PT
oaire.citation.volume13pt_PT
person.familyNameRocha
person.givenNameNuno
person.identifier192266
person.identifier.ciencia-idAE16-A494-5F8B
person.identifier.orcid0000-0002-3139-2786
person.identifier.ridM-9821-2013
person.identifier.scopus-author-id32867975300
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e940914-601a-4978-8d5b-74e5ade7ada7
relation.isAuthorOfPublication.latestForDiscovery9e940914-601a-4978-8d5b-74e5ade7ada7

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