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Antimicrobial and anti-inflammatory activities of Brachydins A-C and root extracts from Fridericia platyphylla

2025-12-16Artigo de investigação Acesso embargado
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dc.contributor.authorLopes, Inês
dc.contributor.authorCampos, Carla
dc.contributor.authorSilva, Fernando
dc.contributor.authorda Costa, Rui M. Gil
dc.contributor.authorFerreira, Layana S.
dc.contributor.authorda Rocha, Cláudia Q.
dc.contributor.authorBrito, Haissa O.
dc.contributor.authorCapela, João Paulo
dc.contributor.authorPinto, Eugénia
dc.contributor.authorMedeiros, Rui
dc.contributor.authorCerqueira, Fátima
dc.date.accessioned2026-05-29T13:15:07Z
dc.date.available2026-05-29T13:15:07Z
dc.date.issued2025-12-16
dc.description.abstractA hydroethanolic extract and its nonpolar dichloromethane fraction obtained from roots of Fridericia platyphylla (Cham.) L.G.Lohmann, Bignoniaceae, were evaluated against yeasts (Candida albicans, C. krusei, and Cryptococcus neoformans), and Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Neither extract showed relevant activity against yeasts or Gram-negative bacteria. In contrast, the dichloromethane fraction exhibited stronger activity against methicillin-sensitive S. aureus (MSSA, ATCC 29213) with minimum inhibitory concentration of 26.7 µg/ml and showed marked antioxidant capacity. Three dimeric flavonoids—brachydins A, B, and C—isolated from dichloromethane fraction displayed potent antimicrobial activity against MSSA ATCC 29213 and V459 strains, with brachydin C being the most active (MIC 12.5 and 75 µM, respectively). Brachydin C also decreased the activity of S. aureus virulence-associated enzymes (DNase and catalase). Extracts and brachydins inhibited nitric oxide (NO) production by LPS-stimulated RAW264.7 macrophages. The in silico ADME profile was further investigated. In conclusion, the results highlight the potential of brachydin C as an anti-staphylococcal agent and the antibacterial, anti-inflammatory and antioxidant potential of F. platyphylla.eng
dc.identifier.citationLopes, I., Campos, C., Silva, F., da Costa, R. M. G., Ferreira, L. S., da Rocha, C. Q., Brito, H. O., Capela, J. P., Pinto, E., Medeiros, R., & Cerqueira, F. (2025). Antimicrobial and anti-inflammatory activities of Brachydins A-C and root extracts from Fridericia platyphylla. Revista Brasileira de Farmacognosia, 36(1), 9. https://doi.org/10.1007/s43450-025-00728-7
dc.identifier.doi10.1007/s43450-025-00728-7
dc.identifier.eissn1981-528X
dc.identifier.issn0102-695X
dc.identifier.urihttp://hdl.handle.net/10400.22/32457
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationUIDB/00511/2020; UIDP/00511/2020; ALiCE, LA/P/0045/2020; UIDB/04423/2020, UIDP/04423/2020; UIDB/04423/2025; UID/ PRR/04423/2025; LA/P/0101/2020
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s43450-025-00728-7
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDimeric flavonoids
dc.subjectAntimicrobial
dc.subjectMinimum inhibitory concentration
dc.subjectVirulence-associated enzymes
dc.titleAntimicrobial and anti-inflammatory activities of Brachydins A-C and root extracts from Fridericia platyphyllaeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.endPage18
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleRevista Brasileira de Farmacognosia
oaire.citation.volume36
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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