Logo do repositório
 
Miniatura
Publicação

Antimicrobial and anti-inflammatory activities of Brachydins A-C and root extracts from Fridericia platyphylla

2025-12-16Artigo de investigação Acesso embargado
http://hdl.handle.net/10400.22/32457
Utilize este identificador para referenciar este registo.
Nome:Descrição:Tamanho:Formato: 
ART_Inês Lopes.pdf1.46 MBAdobe PDF Ver/Abrir

Autores

Lopes, Inês
Campos, Carla
Silva, Fernando
da Costa, Rui M. Gil
Ferreira, Layana S.
da Rocha, Cláudia Q.
Brito, Haissa O.
Capela, João Paulo
Pinto, Eugénia
Medeiros, Rui

Orientador(es)

Resumo(s)

A hydroethanolic extract and its nonpolar dichloromethane fraction obtained from roots of Fridericia platyphylla (Cham.) L.G.Lohmann, Bignoniaceae, were evaluated against yeasts (Candida albicans, C. krusei, and Cryptococcus neoformans), and Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. Neither extract showed relevant activity against yeasts or Gram-negative bacteria. In contrast, the dichloromethane fraction exhibited stronger activity against methicillin-sensitive S. aureus (MSSA, ATCC 29213) with minimum inhibitory concentration of 26.7 µg/ml and showed marked antioxidant capacity. Three dimeric flavonoids—brachydins A, B, and C—isolated from dichloromethane fraction displayed potent antimicrobial activity against MSSA ATCC 29213 and V459 strains, with brachydin C being the most active (MIC 12.5 and 75 µM, respectively). Brachydin C also decreased the activity of S. aureus virulence-associated enzymes (DNase and catalase). Extracts and brachydins inhibited nitric oxide (NO) production by LPS-stimulated RAW264.7 macrophages. The in silico ADME profile was further investigated. In conclusion, the results highlight the potential of brachydin C as an anti-staphylococcal agent and the antibacterial, anti-inflammatory and antioxidant potential of F. platyphylla.

Descrição

Palavras-chave

Dimeric flavonoids Antimicrobial Minimum inhibitory concentration Virulence-associated enzymes

URI

http://hdl.handle.net/10400.22/32457

Contexto Educativo

Citação

Lopes, I., Campos, C., Silva, F., da Costa, R. M. G., Ferreira, L. S., da Rocha, C. Q., Brito, H. O., Capela, J. P., Pinto, E., Medeiros, R., & Cerqueira, F. (2025). Antimicrobial and anti-inflammatory activities of Brachydins A-C and root extracts from Fridericia platyphylla. Revista Brasileira de Farmacognosia, 36(1), 9. https://doi.org/10.1007/s43450-025-00728-7

Projetos de investigação

Unidades organizacionais

Fascículo

Editora

Springer Nature

DOI

10.1007/s43450-025-00728-7

Coleções

ESS - ACSP - Artigos

Licença CC

cclicense-by-nc-nd

Métricas Alternativas