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Advisor(s)
Abstract(s)
188Re is a promising radionuclide for metabolic therapy because of the
emission of high energy beta-particles. The development of water-soluble bone-seeking
polymers such as PEI-MP (polyethyleneimine, functionalised with methylphosphonate-
groups) that might be labeled with 188Re are recent approaches, with a strong potential
for bone cancer treatment. The aim of this study was to evaluate the efficacy of 188Re-
PEI-MP, as therapeutic agent for bone tumours, through in vitro and in vivo models.