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Potentional radiosensitizer effect of TUDCA in a obesity model of brain tumor cells

2014-10Conference object Open access
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dc.contributor.authorSilva, Liliana
dc.contributor.authorAlmeida, Joana
dc.contributor.authorCoelho, Pedro
dc.contributor.authorFaria, Isabel
dc.contributor.authorMonteiro, Armanda
dc.contributor.authorSoares, Raquel
dc.contributor.authorVieira, Mónica
dc.contributor.authorPrudêncio, Cristina
dc.contributor.authorFernandes, Rúben
dc.date.accessioned2022-05-18T15:21:31Z
dc.date.available2022-05-18T15:21:31Z
dc.date.issued2014-10
dc.description.abstractObesity may play an important role in the biology of seve ral types of cancer, but the correlation with glioma Is still not very well defined. Former studies indicated that obesity may be related with an decreased resistance to radiation and increased redox status in brain tumors. Since radiothetapy is the most commonly treatment modality used in this type of tumor, we creale a new model of experiments to determinate the influence of obesity in glioma cells [n the presence of radiation with an imbalance of redox status, BC3H1 glioma cells were treated with t-BOOH (150~M), TUDCA (25~M) and a mix of t-BOOH and TUOCA{150~M and 25~M respectively) in serum-free OMEM or conditioned media (CM) from differentiated 3T3-L 1 adj pocytes. Afterwards the cells were irradiated with a total dose of 2 Gy. Subsequently BC3H1 viability was evaluated, by MTT assay, after 4 and 12 hours. We observed an increase in viability In all cells treated solely with 3T3-L 1 eM. Interestingly, in the presence of CM plus TUDCA or t-BOOH, the viability of 6C3H1 was inferior of TUOCA or t~BOOH treatments alone, this effect was independent of irradia tion. After 12 hours the I/iability of the glioma cells was significantly higher on irradiated ceUs treated only with eM, this effect was not yet observed at the 4 hours time point But, in the presence of mix of t~BOOH and TUDCA, with eM and irradiation the cells viability decrea se significanUy. The 3T3-L 1 Me increase (he cell viabrlity in the presence of radiation or not, after 12 hours expose" But in the presence of oxidatIve inducer and, In specially, with the antioxidant TUDCA, the BC3Hi viability significantly decrease. So, we observed a potential radiosensitfzer effect of TUDCA in BC3H1 in the presence of 3T3-L1 adipocytes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, L., Almeida, J., Coelho, P., Faria, I., Monteiro, A., Soares, R., Vieira, M., Prudêncio, C., & Femandes, R. (2014). Potentional radiosensitizer effect of TUDCA in a obesity model of brain tumor cells. 18º Congresso Português de Obesidade, Aveiro. https://bibliotecadigital.ipb.pt/bitstream/10198/12087/3/Revista%20de%20cirurgia%20Poster%20SPEO%202014.pdfpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/20535
dc.language.isoporpt_PT
dc.publisherSPEOpt_PT
dc.subjectGliomapt_PT
dc.subjectObesitypt_PT
dc.subjectRadiotherapypt_PT
dc.subjectTUDCApt_PT
dc.titlePotentional radiosensitizer effect of TUDCA in a obesity model of brain tumor cellspt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage49pt_PT
oaire.citation.titleRevista Portuguesa de Cirurgia, 18º Congresso Português de Obesidadept_PT
person.familyNameALMEIDA
person.familyNameCoelho
person.familyNameVieira
person.familyNamePrudêncio
person.familyNameFernandes
person.givenNameJOANA
person.givenNamePedro
person.givenNameMónica
person.givenNameCristina
person.givenNameRúben
person.identifier1200571
person.identifier635792
person.identifier.ciencia-id1317-637D-8EE0
person.identifier.ciencia-idBE18-3DB2-8D79
person.identifier.ciencia-idC81E-F4EE-FADE
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.orcid0000-0001-8043-9053
person.identifier.orcid0000-0002-2343-1108
person.identifier.orcid0000-0002-9614-9031
person.identifier.orcid0000-0002-9920-936X
person.identifier.orcid0000-0001-8933-3984
person.identifier.ridAAZ-9239-2020
person.identifier.ridD-8977-2016
person.identifier.scopus-author-id57214054449
person.identifier.scopus-author-id24464652500
person.identifier.scopus-author-id6508057930
person.identifier.scopus-author-id57640135700
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
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