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Medication review improves pain management and quality of life in chronic pain: a pilot randomized controlled study

2025-12-29Research article Open access
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dc.contributor.authorDuarte, Nuno
dc.contributor.authorMartins, João Paulo
dc.contributor.authorGarcía-Domingo, Mónica
dc.contributor.authorA. García-Pedraza, Jose
dc.contributor.authorSantos, Marlene
dc.contributor.authorSantos, Marlene
dc.contributor.authorOliveira Martins, João Paulo
dc.contributor.authorDuarte, Nuno
dc.date.accessioned2026-01-07T17:02:37Z
dc.date.available2026-01-07T17:02:37Z
dc.date.issued2025-12-29
dc.description.abstractChronic pain is a complex condition that benefits from a multidisciplinary approach. This pilot parallel-group single-blinded randomized controlled study evaluated the feasibility, acceptability and adherence by patients and physicians of pharmacist-led medication review on chronic pain patients. Trends in pain intensity, quality of life and patient satisfaction were examined. Twenty adults were recruited from two primary care units in Porto, Portugal, and randomly assigned to either the medication review (MR) group, (n=10) using the Dader method, or the usual care (UC) group, (n=10) and given general advice, for 16-weeks. Pain intensity decreased by 2.07 (MR group) and increased by 0.52 (UC group), yielding an adjusted mean difference of 2.77 (95% CI, -4.93 to -0.62; p=0.008). Pain relief was reported by 62.5% in the MR group versus 37.5% in UC (p=0.357). The MR group showed significant improvement in physical functioning (p=0.019) and higher treatment satisfaction (p=0.029). The acceptance rate of MR interventions was 71%, which resolved 63% of negative medication outcomes. Acceptability was high (>90% of planned interviews). Conducting pharmacist led MR for chronic pain management in primary care is feasible and well accepted by patients and physicians. Observed trends toward improved pain and QoL warrant confirmation in a larger trial. This pilot trial was registered in clinicaltrials.gov (NCT06997861).eng
dc.description.sponsorship18K264/463AC01
dc.identifier.citationDuarte, N., Martins, J. P., García-Domingo, M., García-Pedraza, J. A., & Santos, M. (2025). Medication review improves pain management and quality of life in chronic pain: A pilot randomized controlled study. Scientific Reports, 15(1), 44689. https://doi.org/10.1038/s41598-025-28475-8
dc.identifier.doi10.1038/s41598-025-28475-8
dc.identifier.eissn2045-2322
dc.identifier.urihttp://hdl.handle.net/10400.22/31411
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relationUID/50006/2025
dc.relation.hasversionhttps://www.nature.com/articles/s41598-025-28475-8
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMedication review
dc.subjectChronic pain management
dc.subjectPrimary care
dc.subjectPharmaceutical care
dc.subjectDader method
dc.titleMedication review improves pain management and quality of life in chronic pain: a pilot randomized controlled studyeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.titleScientific Reports
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSantos
person.familyNameOliveira Martins
person.familyNameDuarte
person.givenNameMarlene
person.givenNameJoão Paulo
person.givenNameNuno
person.identifier1508370
person.identifier955929
person.identifier.ciencia-id8311-B967-31C4
person.identifier.ciencia-id6913-C065-48FF
person.identifier.ciencia-id311A-335C-3FCE
person.identifier.orcid0000-0001-5020-5942
person.identifier.orcid0000-0002-0474-1397
person.identifier.orcid0000-0002-9690-0374
person.identifier.scopus-author-id57110502000
person.identifier.scopus-author-id55838096100
relation.isAuthorOfPublication8ce9ee39-a4c6-46ae-99e2-49397b550f1b
relation.isAuthorOfPublication9d1f7388-bb3e-4f1d-bf41-08a589b1d6a8
relation.isAuthorOfPublication7277d917-5b9c-4143-8d6f-8dc02bc71155
relation.isAuthorOfPublication.latestForDiscovery8ce9ee39-a4c6-46ae-99e2-49397b550f1b

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