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Electrochemical determination of citalopram by adsorptive stripping voltammetry–determination in pharmaceutical products
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Orientador(es)
Resumo(s)
The electrochemical behavior of citalopram was studied by square-wave and
square-wave adsorptive-stripping voltammetry (SWAdSV). Citalopram can be reduced
and accumulated at a mercury drop electrode, with a maximum peak current intensity
being obtained at a potential of approximately -1.25V vs. AgCl/Ag, in an aqueous
electrolyte solution of pH 12. A SWAdSV method has been developed for the
determination of citalopram in pharmaceutical preparations. The method shows a
linear range between 1.0x10-7 and 2.0x10-6 mol L-1 with a limit of detection
of 5x10-8 mol L-1 for an accumulation time of 30 s. The precision of the method
was evaluated by assessing the repeatability and intermediate precision, achieving
good relative standard deviations in all cases (≤2.3%). The proposed method was
applied to the determination of citalopram in five pharmaceutical products and the
results obtained are in good agreement with the labeled values.
Descrição
Palavras-chave
Citalopram SSRI Hanging mercury drop electrode Adsorptive-stripping voltammetry Pharmaceutical analysis
Contexto Educativo
Citação
Editora
Taylor & Francis