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DNA-based sensor against nitrite oxide radical: Evaluation of total antioxidant capacity in beverages

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dc.contributor.authorCruz, Diana
dc.contributor.authorBarroso, M. Fátima
dc.contributor.authorRamalhosa, Maria João
dc.contributor.authorCoelho, Andreia
dc.contributor.authorSilva, Hélder da
dc.contributor.authorDuarte, Abel J.
dc.contributor.authorGonzález-García, Maria Begoña
dc.contributor.authorCarvalho, Ana P.
dc.contributor.authorDelerue-Matos, Cristina
dc.date.accessioned2017-01-11T12:12:47Z
dc.date.embargo2116-11
dc.date.issued2016
dc.description.abstractReactive nitrogen and oxygen species are produced in cells and play an important role in the oxidative metabolism; when in abnormal concentrations, they are able to induce oxidative damage on biomolecules, namely in DNA. In this paper it is described, an electrochemical DNA-based sensor against NOradical dot radical developed for total antioxidant capacity (TAC) evaluation. The sensor consisted on dA20 (adenine-rich oligonucleotide) physically adsorbed into carbon paste electrode (CPE). When this dA20-CPE was damaged, by immersion in a freshly generated NOradical dot radical, a protective effect onto dA20 was observed in the presence of antioxidants (ascorbic, gallic, caffeic, p-coumaric acids). Electrochemical studies were performed through square wave voltammetry. The construction of the sensor is simple, fast and the results indicated that the DNA-based sensor is suitable, accurate, and can be used to the assessment of TAC in commercial samples of juices.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.jelechem.2015.12.045pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/9205
dc.language.isoengpt_PT
dc.publisherElsevierpt_PT
dc.relation.ispartofseriesJournal of Electroanalytical Chemistry;Vol. 763
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1572665715302654pt_PT
dc.subjectDNA-based sensorpt_PT
dc.subjectReactive nitrogen and oxygen speciespt_PT
dc.subjectElectrochemistrypt_PT
dc.subjectTotal antioxidant capacity (TAC)pt_PT
dc.subjectCommercial juice samplespt_PT
dc.titleDNA-based sensor against nitrite oxide radical: Evaluation of total antioxidant capacity in beveragespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage115pt_PT
oaire.citation.startPage110pt_PT
oaire.citation.titleJournal of Electroanalytical Chemistrypt_PT
oaire.citation.volume763pt_PT
person.familyNamede Sá Barroso
person.familyNameRamalhosa
person.familyNameDelerue-Matos
person.givenNameMaria de Fátima
person.givenNameMaria João
person.givenNameCristina
person.identifier.ciencia-idAF16-22E5-5EBD
person.identifier.ciencia-id421A-C491-F45B
person.identifier.ciencia-id9A1A-43FB-5C27
person.identifier.orcid0000-0001-9011-5992
person.identifier.orcid0000-0002-1951-3557
person.identifier.orcid0000-0002-3924-776X
person.identifier.ridD-8293-2013
person.identifier.ridD-4990-2013
person.identifier.scopus-author-id25631648000
person.identifier.scopus-author-id35488836000
person.identifier.scopus-author-id6603741848
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3d701c85-4580-4614-be6d-5a1abc8cf729
relation.isAuthorOfPublicationda678924-3a20-496e-bc38-a9e2b39399b8
relation.isAuthorOfPublication09f6a7bd-2f15-42b0-adc5-04bd22210519
relation.isAuthorOfPublication.latestForDiscovery09f6a7bd-2f15-42b0-adc5-04bd22210519

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