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New insights into the oxidation pathways of apomorphine
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A detailed study of the oxidative behaviour of apomorphine in aqueous media is reported. Resorting to the synthesis
of apomorphine derivatives it was possible to identify all the anodic oxidation peaks of apomorphine, which are
related to the oxidation of the catechol and tertiary amine groups. These findings were revealed to be important since
they could lead to a better understanding of the biological interactions of apomorphine and gain insight into its
metabolic pathways. During the voltammetric studies, it was also found that apomorphine forms a complex with
borate through the catechol group leading to an increase of its oxidation potential. This property could be very useful
with regard to the stabilization of apomorphine solutions since it could drastically reduce its autoxidation.
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The Royal Society of Chemistry