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The synergic effect of antibiotics is dependent of oxidative stress genes in Pseudomonas aeruginosa

2021Conference object Open access
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dc.contributor.authorFernandes, Rúben
dc.contributor.authorCoelho, Pedro Barata
dc.contributor.authorGuedes, Carla
dc.contributor.authorGojon, Frantz
dc.contributor.authorOliveira, Marco
dc.contributor.authorVeiga, Marlene
dc.contributor.authorSá, Sara
dc.contributor.authorSilva, Carina
dc.contributor.authorBaylina, Pilar
dc.date.accessioned2024-10-15T14:14:19Z
dc.date.available2024-10-15T14:14:19Z
dc.date.issued2021
dc.description.abstractPseudomonas aeruginosa is a Gram-negative opportunistic pathogen commonly found in Cystic fibrosis, infected wound of the diabetic foot among others. Clinical management of such infection depends deeply on the antibiotic therapy. Antibiotic response is dependent, among several other factors, to the response to host stress conditions, such as low-grade inflammation, metabolic conditions and oxidative stress and to social bacteria response such as quorum sensing and biofilm formation. P. aeruginosa, in particular strain PAO1 is also a biological model for studying bacterial biofilm formation. The present study aims to understand the antibiotic synergic response (ampicillin, ceftazidime, ciprofloxacin) in biofilm formation / degradation of 10 PAO1 oxidative gene mutants. Viability was measured by means of Erythrosin B and biofilm formation was measured by Crystal Violet assay. PAO1 GRLX, SEPHS 1, Rub A1, where the strains with a most pronounced biofilm formation and combination of ceftazidme::ciprofloxacin were most efficient in this biological model. The results are interesting, and although they are encouraging, they should be taken with caution.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFernandes, R., Coelho, P. B., Guedes, C., Gojon, F., Oliveira, M., Veiga, M., Sa, S., Silva, C., & Baylina, P. (2021). The synergic effect of antibiotics is dependent of oxidative stress genes in Pseudomonas aeruginosa. Livro de resumos XXVIII Congreso Nacional de Microbiología, 210.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.22/26245
dc.language.isoengpt_PT
dc.publisherSociedade Espanhola de Microbiologiapt_PT
dc.relation.publisherversionhttps://digital.csic.es/bitstream/10261/270690/1/XVIII-Congreso-Nacional-de-Microbiologi%CC%81a-FINAL-7.pdfpt_PT
dc.subjectPseudomonas aeruginosapt_PT
dc.subjectCystic fibrosispt_PT
dc.titleThe synergic effect of antibiotics is dependent of oxidative stress genes in Pseudomonas aeruginosapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.startPage210pt_PT
oaire.citation.titleLivro de resumos XXVIII Congreso Nacional de Microbiologíapt_PT
person.familyNameFernandes
person.familyNameBAYLINA MACHADO
person.givenNameRúben
person.givenNamePILAR
person.identifier635792
person.identifier.ciencia-id0D1F-4090-E82A
person.identifier.ciencia-id1419-F23D-4920
person.identifier.orcid0000-0001-8933-3984
person.identifier.orcid0000-0002-3740-862X
person.identifier.ridB-5134-2010
person.identifier.scopus-author-id57640135700
person.identifier.scopus-author-id56534079700
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4
relation.isAuthorOfPublicationb1482a24-d9d8-419d-af68-6df1a75afb3f
relation.isAuthorOfPublication.latestForDiscovery9e6c397c-62d8-4a40-8ec7-ad05ae0ebcc4

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